Standing on the shoulders of giants: The changing landscape of pluripotent stem cells in research.
Standing on the shoulders of giants: The changing landscape of pluripotent stem cells in research.
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站在巨人的肩膀上：多能干细胞研究中不断变化的景观。
DOI：
10.1002/ar.24304
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Clark,AmanderT
中科院分区：
文献类型：
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作者：
Clark,AmanderT
干细胞具有自我更新和分化的显著特性。几十年来，这两个基本方面一直让科学家和临床医生兴奋不已。干细胞是由它们的潜能定义的，多能性是最允许的，而单能性是最受限制的。在哺乳动物中，多能性代表在植入前和植入后早期胚胎中发现的细胞类型。然而，这些多能细胞不是干细胞，因为它们不符合自我更新的标准。因此，多能干细胞在体外细胞类型中是独一无二的，这为科学家和临床医生提供了前所未有的能力来研究多能性的基本细胞和分子特性，以及提供了细胞分化的窗口和再生医学的细胞来源，包括可用于再生肾脏的细胞类型。
Stem cells have the remarkable property of self‐renewal and differentiation. These two fundamental aspects have excited scientists and clinicians for decades. Stem cells are defined by their potency, with pluripotency being the most permissive and unipotency being the most restricted. In mammals, pluripotency represents cell types found in the preimplantation and early postimplantation embryo. However, these pluripotent cells are not stem cellsper se, because they do not meet the criteria of self‐renewal. Therefore, pluripotent stem cells are exclusivelyin vitrocell types that have provided scientists and clinicians with unprecedented power to study the fundamental cell and molecular properties of pluripotency, as well as providing a window into cellular differentiation and a source of cells for regenerative medicine including cell types that could be used to regenerate the kidney.