Toll-like receptor 4 plays no role in susceptibility of mice to Mycobacterium tuberculosis infection
Toll-like receptor 4 plays no role in susceptibility of mice to Mycobacterium tuberculosis infection
复制标题
DOI：
10.1016/s1472-9792(03)00071-4
复制
发表时间：
2003-01-01
期刊：
影响因子：
3.2
通讯作者：
Orme, IM
中科院分区：
文献类型：
--
作者：
Shim, TS;Turner, OC;Orme, IM
尽管模式识别Toll样受体（TLR）家族的各种成员与宿主对结核分枝杆菌感染的抗性有关，但TLR 4受体是否起重要作用仍不清楚。我们在这里证明，在C3 H近交系小鼠品系背景下感染TRL 4-感受态和TLR 4-缺陷型小鼠具有相似的结果，在疾病过程、肺部细胞积聚模式和肺组织病理学方面进行测量。这些数据反驳了TLR 4在小鼠模型中对结核病免疫中的重要作用。(C)2003 Elsevier Ltd.保留所有权利。
Although various members of the pattern recognition Toll-like receptor (TLR) family have been implicated in host resistance to Mycobacterium tuberculosis infection, it remains unclear if the TLR4 receptor plays an important role. We demonstrate here that infection of TRL4-competent and TLR4-deficient mice on the C3 H inbred mouse strain background had similar outcomes, measured in terms of the course of the disease, cell accumulation patterns in the lungs, and lung histopathology. These data argue against a significant role for TLR4 in immunity to tuberculosis in the mouse model. (C) 2003 Elsevier Ltd. All rights reserved.