Endocrine and cytokine correlates of major depression and dysthymia with typical or atypical features
Endocrine and cytokine correlates of major depression and dysthymia with typical or atypical features
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DOI：
10.1038/sj.mp.4000436
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发表时间：
1999-03-01
影响因子：
11
通讯作者：
Merali, Z
中科院分区：
文献类型：
--
作者：
Anisman, H;Ravindran, AV;Merali, Z
抑郁症与免疫功能各个方面的抑制和增强有关。确定与抑郁症相关的细胞因子改变（包括白细胞介素 1 (IL-1 beta) 和白细胞介素 2 (IL-2)）是否与植物神经症状或疾病的慢性相关是很有意义的。在具有典型或非典型特征的经典重度抑郁症、非典型抑郁症（即具有逆转的植物神经特征）和心境恶劣（无共病重度抑郁症的慢性抑郁症）以及非抑郁对照受试者中，评估了循环ACTH、皮质醇、去甲肾上腺素（NE）和肾上腺素水平，以及促细胞分裂原刺激的淋巴细胞产生IL-1β和IL-2。在非典型抑郁症患者中，与对照组相比，血浆 ACTH 水平升高，而皮质醇水平降低。无论植物神经状况如何，心境恶劣患者的 IL-1 β 产生增加，并且与发病年龄和病程高度相关。相比之下，各组的 IL-2 产生量均减少，但非典型重度抑郁症的减少程度较低。此外，抑郁组中 IL-2 的产生与血浆 NE 水平直接相关，虽然抑郁情绪本身和植物神经特征都不能解释这种影响，但疾病的长期性或发病年龄似乎与细胞因子的改变有关。鉴于循环细胞因子影响神经内分泌功能，并可能影响神经植物特征，白细胞介素可能在抑郁症某些亚型的病理生理学中发挥作用。
Depression has been associated with both suppression and enhancement of various aspects of immune functioning. It was of interest to determine whether cytokine alterations associated with depression, including interleukin-1 (IL-1 beta) and interleukin-2 (IL-2), were related to the neurovegetative symptom profile or to the chronicity of the illness. Circulating ACTH, cortisol, norepinephrine (NE) and epinephrine levels, and production of IL-1 beta and IL-2 from mitogen-stimulated lymphocytes were assessed in classical major depression, atypical depression (ie. with reversed neurovegetative features), and dysthymia (chronic depression without comorbid major depression) with either typical or atypical profiles, as well as nondepressed control subjects. Among atypical depressives, plasma ACTH levels were elevated while cortisol was reduced relative to controls. Irrespective of neurovegetative profile, IL-1 beta production was increased in dysthymic patients, and was highly correlated with age-of-onset and duration of illness. In contrast, IL-2 production was reduced in each of the groups, although less so among atypical major depressives. Moreover, IL-2 production in the depressive groups was directly related to plasma NE levels, While neither depressed mood per se nor neurovegetative features accounted for this effect, it seemed likely that chronicity of illness or age-of-onset were associated with cytokine alterations. Given that circulating cytokines influence neuroendocrine functioning, and may affect neurovegetative features, a role for interleukins may exist with respect to the pathophysiology of certain subtypes of depression.