Effect of quinine on mitochondrial K+ and Mg++ flux.
Effect of quinine on mitochondrial K+ and Mg++ flux.
复制标题
奎宁对线粒体钾和镁通量的影响。
DOI：
10.1016/0006-291x(86)91003-x
复制
发表时间：
1986
影响因子：
3.1
通讯作者：
Diwan,JJ
中科院分区：
文献类型：
--
作者：
Diwan,JJ
奎宁降低单向 K+ 流入和流出大鼠肝线粒体呼吸的速率。 K+流出对奎宁比K+流入更敏感。这些数据与两种不同的机制可能介导钾离子流入的提议一致，其中只有一种对奎宁敏感。立体异构体奎尼丁对 K+通量的影响与奎宁的影响相似。较小的奎宁环在相同条件下至多引起K+流出的轻微抑制。 Mg++flux 表现出与 K+flux 相似的奎宁抑制模式。 Mg++流出对奎宁比Mg++流入更敏感。这些和早期的发现表明肝脏线粒体 K+ 和 Mg++ 转运机制之间存在显着相似性。
Quinine decreases rates of unidirectional K+flux into and out of respiring rat liver mitochondria. K+efflux is more sensitive to quinine than K+influx. The data are consistent with the proposal that two separate mechanisms may mediate K+influx, only one of which is sensitive to quinine. Effects on K+flux of the stereoisomer quinidine are similar to effects of quinine. The smaller quinuclidine causes at most a slight inhibition of K+efflux under the same conditions. Mg++flux exhibits a pattern of inhibition by quinine similar to that of K+flux. Mg++efflux is more sensitive to quinine than is Mg++influx. These and earlier findings indicate marked similarities between liver mitochondrial transport mechanisms for K+and Mg++.