Effect of water, sanitation, handwashing and nutrition interventions on enteropathogens in children 14 months old: a cluster-randomized controlled trial in rural Bangladesh.
Effect of water, sanitation, handwashing and nutrition interventions on enteropathogens in children 14 months old: a cluster-randomized controlled trial in rural Bangladesh.
复制标题
DOI：
10.1093/infdis/jiaa549
复制
发表时间：
2020-08-29
期刊：
影响因子：
--
通讯作者：
中科院分区：
文献类型：
--
作者：
我们评估了低成本的水，卫生和洗手（WSH）和儿童营养干预措施对肠道病原体携带的影响，在孟加拉国农村的WASH福利群随机对照试验。我们使用定量聚合酶链反应分析了WSH组（n = 369）、营养咨询加脂质营养补充剂组（n = 353）、营养加WSH组（n = 360）和对照组（n =329）中14 ±2个月儿童的1411份常规粪便样本中34种肠道病原体。 结果包括共存病原体的数量; 4种发育迟缓相关病原体的累积数量;以及单个病原体的患病率和数量。326名（99.1%）对照儿童检测到1种或多种肠道病原体（平均3.8 ± 1.8）。与对照组相比，接受WSH干预的儿童个体病毒的患病率和数量较低（诺如病毒的患病率差异：-11% [95%置信区间{CI}，-5%至-17%];沙波病毒：-9% [95% CI，-3%至-15%];腺病毒40/41：-9% [95% CI，-2%至-15%]）。对照组和任何干预组之间的细菌、寄生虫或发育迟缓相关病原体的累积数量没有差异。WSH干预与14个月龄儿童的肠道病毒较少相关。在这个关键的年轻时期，需要采取不同的策略来减少肠道细菌和寄生虫。我们评估了水，卫生和洗手（WSH）和营养干预措施对孟加拉国儿童肠道病原体的影响。与对照组相比，WSH干预与较少的肠道病毒相关。WSH或营养干预在细菌和原生动物病原体方面没有差异。
We evaluated the impact of low-cost water, sanitation, and handwashing (WSH) and child nutrition interventions on enteropathogen carriage in the WASH Benefits cluster-randomized controlled trial in rural Bangladesh. We analyzed 1411 routine fecal samples from children 14 ± 2 months old in the WSH (n = 369), nutrition counseling plus lipid-based nutrient supplement (n = 353), nutrition plus WSH (n = 360), and control (n = 329) arms for 34 enteropathogens using quantitative polymerase chain reaction. Outcomes included the number of co-occurring pathogens; cumulative quantity of 4 stunting-associated pathogens; and prevalence and quantity of individual pathogens. Masked analysis was by intention-to-treat. Three hundred twenty-six (99.1%) control children had 1 or more enteropathogens detected (mean, 3.8 ± 1.8). Children receiving WSH interventions had lower prevalence and quantity of individual viruses than controls (prevalence difference for norovirus: –11% [95% confidence interval {CI}, –5% to –17%]; sapovirus: –9% [95% CI, –3% to –15%]; and adenovirus 40/41: –9% [95% CI, –2% to –15%]). There was no difference in bacteria, parasites, or cumulative quantity of stunting-associated pathogens between controls and any intervention arm. WSH interventions were associated with fewer enteric viruses in children aged 14 months. Different strategies are needed to reduce enteric bacteria and parasites at this critical young age. We evaluated the impact of water, sanitation, and handwashing (WSH) and nutrition interventions on enteropathogens in children in Bangladesh. WSH interventions were associated with fewer enteric viruses compared to controls. There was no difference in bacterial and protozoan pathogens for WSH or nutrition interventions.
登录
查看更多内容
DOI：
10.1093/cid/ciw542
发表时间：
2016-11-01
期刊：
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
影响因子：
--
作者：
Amour C;Gratz J;Mduma E;Svensen E;Rogawski ET;McGrath M;Seidman JC;McCormick BJ;Shrestha S;Samie A;Mahfuz M;Qureshi S;Hotwani A;Babji S;Trigoso DR;Lima AA;Bodhidatta L;Bessong P;Ahmed T;Shakoor S;Kang G;Kosek M;Guerrant RL;Lang D;Gottlieb M;Houpt ER;Platts-Mills JA;Etiology, Risk Factors, and Interactions of Enteric Infections and Malnutrition and the Consequences for Child Health and Development Project (MAL-ED) Network Investigators
通讯作者：
Etiology, Risk Factors, and Interactions of Enteric Infections and Malnutrition and the Consequences for Child Health and Development Project (MAL-ED) Network Investigators
影响因子：
6.7
作者：
Endt K;Stecher B;Chaffron S;Slack E;Tchitchek N;Benecke A;Van Maele L;Sirard JC;Mueller AJ;Heikenwalder M;Macpherson AJ;Strugnell R;von Mering C;Hardt WD
通讯作者：
Hardt WD
DOI：
10.1093/cid/ciy320
发表时间：
2018-10-30
期刊：
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
影响因子：
--
作者：
Lin A;Ercumen A;Benjamin-Chung J;Arnold BF;Das S;Haque R;Ashraf S;Parvez SM;Unicomb L;Rahman M;Hubbard AE;Stewart CP;Colford JM Jr;Luby SP
通讯作者：
Luby SP
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y
DOI：
10.1016/s0140-6736(16)31529-x
发表时间：
2016-09-24
期刊：
Lancet (London, England)
影响因子：
--
作者：
Liu J;Platts-Mills JA;Juma J;Kabir F;Nkeze J;Okoi C;Operario DJ;Uddin J;Ahmed S;Alonso PL;Antonio M;Becker SM;Blackwelder WC;Breiman RF;Faruque AS;Fields B;Gratz J;Haque R;Hossain A;Hossain MJ;Jarju S;Qamar F;Iqbal NT;Kwambana B;Mandomando I;McMurry TL;Ochieng C;Ochieng JB;Ochieng M;Onyango C;Panchalingam S;Kalam A;Aziz F;Qureshi S;Ramamurthy T;Roberts JH;Saha D;Sow SO;Stroup SE;Sur D;Tamboura B;Taniuchi M;Tennant SM;Toema D;Wu Y;Zaidi A;Nataro JP;Kotloff KL;Levine MM;Houpt ER
通讯作者：
Houpt ER