Macrophage migration inhibitory factor in cardiovascular disease
Macrophage migration inhibitory factor in cardiovascular disease
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DOI：
10.1161/circulationaha.107.729125
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发表时间：
2008-03-25
期刊：
影响因子：
37.8
通讯作者：
Weber, Christian
中科院分区：
文献类型：
--
作者：
Zernecke, Alma;Bernhagen, Juergen;Weber, Christian
巨噬细胞移动抑制因子（MIF）是一种高度保守、典型但非典型的细胞因子，在许多急性和慢性炎症性疾病中发挥着多效性免疫功能。最近的证据已经出现从表达和功能的研究牵连在心血管疾病的各个方面的MIF。本文综述了MIF在动脉粥样硬化炎症发病机制中的作用及其后果，即不稳定斑块形成、动脉损伤后重塑、动脉瘤形成、心肌梗死或缺血再灌注损伤。此外，其他形式的心肌功能障碍和炎症和血管生成中的MIF的作用进行了审查。的功能数据与最近的进展相一致，在鉴定的七螺旋（CXC趋化因子）受体的MIF，其原型的作用，其非典型的配体，其信号转导的操作在致动脉粥样硬化和炎症招募单核细胞和心肌细胞的氧化损伤和凋亡。其独特的特征和功能清楚地将MIF与其他参与动脉粥样硬化形成的细胞因子区分开来，并使其成为实现动脉粥样硬化治疗消退的主要靶点。针对或利用MIF用于治疗策略或作为心血管疾病或病症的管理中的诊断标志物的潜力被仔细审查。
The highly conserved and archetypical yet atypical cytokine macrophage migration inhibitory factor (MIF) fulfills pleiotropic immune functions in many acute and chronic inflammatory diseases. Recent evidence has emerged from both expression and functional studies to implicate MIF in various aspects of cardiovascular disease. The present review is aimed at providing a synopsis of the involvement of MIF in the inflammatory pathogenesis of atherosclerosis and its consequences, namely unstable plaque formation, remodeling after arterial injury, aneurysm formation, myocardial infarction, or ischemia-reperfusion injury. In addition, other forms of myocardial dysfunction and inflammation and the role of MIF in angiogenesis are reviewed. The functional data are reconciled with recent progress in the identification of heptahelical (CXC chemokine) receptors for MIF, its prototypic role as their noncanonical ligand, and its signal transduction profile operative in atherogenic and inflammatory recruitment of mononuclear cells and in the oxidative damage and apoptosis of cardiomyocytes. Its unique features and functions clearly distinguish MIF from other cytokines implicated in atherogenesis and make it a prime target for achieving therapeutic regression of atherosclerosis. The potential of targeting or exploiting MIF for therapeutic strategies or as a diagnostic marker in the management of cardiovascular diseases or disorders is scrutinized.