Periconceptional use of cod liver oil, a vitamin D source, could decrease the risk of CHD in offspring
Periconceptional use of cod liver oil, a vitamin D source, could decrease the risk of CHD in offspring
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围孕期使用鱼肝油（一种维生素 D 来源）可降低后代患冠心病的风险
DOI：
10.1017/s1047951120002280
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发表时间：
2020-08
影响因子：
1
通讯作者：
Li Shenghui
中科院分区：
文献类型：
--
作者：
Zhao Anda;Zhao Kena;Xia Yuanqing;Yin Yong;Zhu Jianzhen;Hong Haifa;Li Shenghui
目的：探讨围受孕期通过摄入鱼肝油补充维生素D与后代发生严重CHD的风险之间是否存在相关性。此外，我们将研究维生素D和叶酸补充剂之间的相互作用。研究方法：于2016年6月至2017年12月在上海儿童医学中心进行了一项病例对照研究，其中共招募了262例重度CHD病例和262例对照。所有儿童均小于2岁。为了减少潜在的选择偏倚并最大限度地减少混杂效应，应用了倾向评分匹配。结果如下：多因素条件Logistic回归分析显示，在倾向评分匹配后，补充维生素D似乎与严重CHD的比值比降低有关（比值比= 0.666，95%可信区间：0.449-0.990）。此外，我们发现维生素D和叶酸补充剂之间存在相互作用（相互作用导致的相对超额风险= 0.810，95%置信区间：0.386-1.235）。结论：提示母亲补充维生素D可降低子代发生重度CHD的风险，并可加强叶酸的保护作用。这项研究的意义在于提供流行病学证据，围怀孕期补充维生素D可能是一种潜在的营养干预策略，以应对日益增加的CHD的挑战。
Objective: To explore if there is association between vitamin D supplementation through cod liver oil ingestion around the periconceptional period and the risk of developing severe CHD in offspring. Furthermore, we would examine the interaction between vitamin D and folic acid supplementation in the association. Methods: A case-control study was conducted in Shanghai Children's Medical Center, in which, a total of 262 severe CHD cases versus 262 controls were recruited through June 2016 to December 2017. All children were younger than 2 years. To reduce potential selection bias and to minimise confounding effects, propensity score matching was applied. Results: After propensity score matching, vitamin D supplementation seemed to be associated with decreased odds ratio of severe CHD (odds ratio = 0.666; 95% confidence intervals: 0.449-0.990) in the multivariable conditional logistic analysis. Furthermore, we found an additive interaction between vitamin D and folic acid supplementation (relative excess risk due to interaction = 0.810, 95% confidence intervals: 0.386-1.235) in the association. Conclusion: The results suggested that maternal vitamin D supplementation could decrease the risk of offspring severe CHD; moreover, it could strengthen the protective effect of folic acid. The significance of this study lies in providing epidemiological evidence that vitamin D supplementation around the periconceptional period could be a potential nutritional intervention strategy to meet the challenge of increasing CHD.
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DOI：
10.1002/dvdy.24639
发表时间：
2018-08
期刊：
Developmental dynamics : an official publication of the American Association of Anatomists
影响因子：
--
作者：
Wang S;Huang W;Castillo HA;Kane MA;Xavier-Neto J;Trainor PA;Moise AR
通讯作者：
Moise AR
DOI：
10.1177/1352458515578770
发表时间：
2015-12
期刊：
Multiple sclerosis (Houndmills, Basingstoke, England)
影响因子：
--
作者：
Cortese M;Riise T;Bjørnevik K;Holmøy T;Kampman MT;Magalhaes S;Pugliatti M;Wolfson C;Myhr KM
通讯作者：
Myhr KM
影响因子：
3.7
作者：
Mao B;Qiu J;Zhao N;Shao Y;Dai W;He X;Cui H;Lin X;Lv L;Tang Z;Xu S;Huang H;Zhou M;Xu X;Qiu W;Liu Q;Zhang Y
通讯作者：
Zhang Y
影响因子：
8.8
作者：
Cortes M;Chen MJ;Stachura DL;Liu SY;Kwan W;Wright F;Vo LT;Theodore LN;Esain V;Frost IM;Schlaeger TM;Goessling W;Daley GQ;North TE
通讯作者：
North TE
影响因子：
1.9
作者：
S. Kubow
通讯作者：
S. Kubow