Is sporadic Alzheimer disease the brain type of non-insulin dependent diabetes mellitus? A challenging hypothesis
Is sporadic Alzheimer disease the brain type of non-insulin dependent diabetes mellitus? A challenging hypothesis
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DOI：
10.1007/s007020050067
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发表时间：
1998-01-01
影响因子：
3.3
通讯作者：
Hoyer, S
中科院分区：
文献类型：
--
作者：
Hoyer, S
提出了散发性迟发性阿尔茨海默病是由局限于脑的非胰岛素依赖型糖尿病引起的假说。这一假设是基于Frolich及其同事的发现（本卷），他们清楚地证明了神经元胰岛素/胰岛素受体信号转导通路的扰动，这被认为是阿尔茨海默氏症大脑中葡萄糖/能量代谢急剧减少的病理生物化学基础。由于这种异常，形成晚期糖基化终产物。蒙克等人（本卷）评估了后者与氧化应激和β-淀粉样蛋白和神经纤维缠结形成有关的影响。
The hypothesis is forwarded that sporadic late-onset Alzheimer disease is caused by non-insulin dependent diabetes mellitus which is confined to the brain. This hypothesis is based on the findings of Frolich and coworkers (this volume) who clearly demonstrate a perturbation of the neuronal insulin/ insulin receptor signal transduction pathway which is considered to be the pathobiochemical basis for the drastic reduction in glucose/energy metabolism in Alzheimer brain. As a consequence of this abnormality, advanced glycation end products are formed. Munch et al. (this volume) evaluate the impacts of the latter related to oxidative stress and the formation of P-amyloid and neurofibrillary tangles.