Variations in the obesity genes FTO, TMEM18 and NRXN3 influence the vulnerability of children to weight gain induced by short sleep duration
Variations in the obesity genes FTO, TMEM18 and NRXN3 influence the vulnerability of children to weight gain induced by short sleep duration
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DOI：
10.1038/ijo.2012.27
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发表时间：
2013-02-01
影响因子：
4.9
通讯作者：
Lopez-Bermejo, A.
中科院分区：
文献类型：
--
作者：
Prats-Puig, A.;Grau-Cabrera, P.;Lopez-Bermejo, A.
目的：睡眠时间较短易导致肥胖，但睡眠剥夺影响体重的机制尚不清楚。我们测试了这种关联是否受到肥胖基因FTO、TMEM18和NRXN3的调节。研究对象：对297名无症状儿童（151名男孩，146名女孩，年龄范围5-9岁，BMI sd评分范围-2.0-4.0）的体重指数（BMI）、腰围、内脏脂肪（腹部超声）、胰岛素抵抗稳态模型评估（HOMA-IR）、收缩压（SBP）和每24小时睡眠时间进行评估。我们测试了三种常见的单核苷酸多态性（snp），即FTO （rs9939609）、TMEM 18 （rs4854344）和NRXN3 (rs10146997)，以及它们的组合，以确定睡眠时间与上述结果之间的关系。结果：FTO SNP的TT纯合子（但不是A*携带者）在睡眠时间减少与BMI、腰围、内脏脂肪和HOMA-IR增加之间表现出名义上的关联
OBJECTIVE: Shorter sleep duration predisposes to obesity, but the mechanisms whereby sleep deprivation affects body weight are poorly understood. We tested whether this association is modulated by the obesity genes FTO, TMEM18 and NRXN3.SUBJECTS: Body mass index (BMI), waist circumference, visceral fat (abdominal ultrasound), homeostasis model assessment for insulin resistance (HOMA-IR), systolic blood pressure (SBP) and sleep time per 24 h were assessed in 297 asymptomatic children (151 boys, 146 girls; age range 5-9 years; BMI s.d. score range -2.0-4.0). Associations between sleep duration and the abovementioned outcomes were tested for three common single-nucleotide polymorphisms (SNPs), namely FTO (rs9939609), TMEM 18 (rs4854344) and NRXN3 (rs10146997), as well as for their combination.RESULTS: TT homozygotes (but not A* carriers) for the FTO SNP, exhibited nominal associations between decreasing sleep duration and increasing BMI, waist circumference, visceral fat and HOMA-IR (all P