The role of human papillomavirus on sperm function
The role of human papillomavirus on sperm function
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DOI：
10.1097/gco.0b013e328348a3a4
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发表时间：
2011-08-01
影响因子：
2.1
通讯作者：
Foresta, Carlo
中科院分区：
文献类型：
--
作者：
Garolla, Andrea;Pizzol, Damiano;Foresta, Carlo
综述目的回顾人乳头瘤病毒（HPV）对精子参数的作用，最近的发现HPV是最常见的性传播疾病的病原体，可导致男性和女性的疣和癌症。HPV感染的高发病率已被证明在性活跃的男性和无HPV危险因素的男性的精子中，以及在性活跃的男性和女性的精子中，HPV感染的高发病率已被证明在性活跃的男性和女性的精子中，HPV感染的高发病率已被证明在性活跃的男性和女性的精子中。不孕症患者精液感染与精子参数受损相关，提示可能在男性不育中起作用。有趣的是，已经证明，当HPV存在于精液中时，只有一部分细胞被感染，并且病毒可以定位在精子或脱落细胞中，对精子活力有不同的影响。此外，受感染的精子能够穿透卵母细胞，将HPV基因组递送到卵母细胞中，并且HPV基因可以由受精卵母细胞主动转录。最近，在接受体外受精的夫妇中，特别是当男性伴侣的精液样本中存在HPV DNA时，已经证明了妊娠丢失的风险增加。尽管报告了HPV精液感染的高发病率，但为男性提供了控制策略和预防。由于男性的这种感染对伴侣也是一个问题，而且越来越多的证据表明精液感染可能导致不孕和早期流产，因此应更多地关注男性HPV感染。本研究回顾了HPV感染对精子功能和人类生殖作用的最新文献。
Purpose of reviewTo review the role of human papillomavirus (HPV) on sperm parameters, fertility and implication of the use of infected sperm cells in assisted reproduction.Recent findingsHPVs are agents of the most common sexually transmitted disease and can lead to warts and cancers both in men and women.A high incidence of HPV infection has been demonstrated in sperm from sexually active men with and without risk factors for HPV and from infertile patients. Semen infection is associated to an impairment of sperm parameters suggesting a possible role in male infertility. Interestingly, it has been demonstrated that when HPV is present in semen only a percentage of total cells are infected and the virus can be localized in sperm or in exfoliated cells with different impact on sperm motility. Moreover, infected sperm are able to penetrate the oocyte, to deliver HPV genome in the oocyte and HPV genes can be actively transcribed by the fertilized oocyte.Recently an increased risk of pregnancy loss has been demonstrated in couples undergoing in-vitro fertilization and particularly when HPV DNA was present in semen samples of male partners.SummaryTo date, no effective treatment, control strategy and prevention is provided for men despite the reported high incidence of HPV semen infection. Because this infection in men is also a problem for partners, and because growing evidence suggests that semen infection may cause infertility and early miscarriage, more attention should be paid to male HPV infection. This study reviews the more recent literature about the role of HPV infection on sperm function and human reproduction.