Conservation of T cell receptor conformation in epidermal γδ cells with disrupted primary Vγ gene usage
Conservation of T cell receptor conformation in epidermal γδ cells with disrupted primary Vγ gene usage
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DOI：
10.1126/science.279.5357.1729
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发表时间：
1998-03-13
期刊：
影响因子：
56.9
通讯作者：
Hayday, AC
中科院分区：
文献类型：
--
作者：
Mallick-Wood, CA;Lewis, JM;Hayday, AC
将γ δ T细胞亚群与大多数α β T细胞和B细胞区分开的特征是单个T细胞受体（TCR）γ和δ可变（V）区基因区段的表达与特定解剖学位点的关联。缺乏大多数树突状表皮T细胞正常表达的TCR V（γ）5链的小鼠显示出保留了确定的构象。与特定解剖学位点相关的独特型的改组γ δ TCR链的保守性表明，对于TCR γ δ，如同对于免疫球蛋白一样，与特定基因片段的使用相比，构象与淋巴细胞库的功能或发育的关联程度更大。
A feature that distinguishes gamma delta T cell subsets from most alpha beta T cells and B cells is the association of expression of single T cell receptor (TCR) gamma and delta variable (V) region gene segments with specific anatomic sites. Mice lacking the TCR V(gamma)5 chain normally expressed by most dendritic epidermal T cells were shown to retain a conformational determined (idiotype) ordinarily expressed exclusively by such V(gamma)5(+) cells, Conservation by shuffled gamma delta TCR chains of an idiotype associated with a specific anatomic site indicates that for TCR gamma delta, as for immunoglobulin, conformation is associated to a greater extent with the function or development of lymphocyte repertoires than is the use of particular gene segments.