Antifungal drug screening: thinking outside the box to identify novel antifungal scaffolds.
Antifungal drug screening: thinking outside the box to identify novel antifungal scaffolds.
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DOI：
10.1016/j.mib.2020.03.005
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发表时间：
2020-10
影响因子：
5.4
通讯作者：
Krysan DJ
中科院分区：
文献类型：
--
作者：
Beattie SR;Krysan DJ
侵袭性真菌感染是造成世界范围内重大疾病负担的原因。治疗这些感染的药物仅限于四种独特的类别，尽管有这些可用的治疗方法，死亡率仍然高得令人无法接受。在这篇综述中，我们将讨论抗真菌药物筛选以及如何识别新化合物的方法需要从传统的基于生长的分析中转移，以满足对新药的需求。我们强调了创造性筛选策略的具体例子，这些策略增加了识别具有所需活性的化合物的可能性，并为激发鉴定一流抗真菌药物的新筛选的开发提供了视角。
Invasive fungal infections are responsible for a significant disease burden worldwide. Drugs to treat these infections are limited to only four unique classes, and despite these available treatments, mortality rates remain unacceptably high. In this review, we will discuss antifungal drug screening and how the approach to identifying novel compounds needs move away from traditional growth-based assays in order to meet the demand for new drugs. We highlight specific examples of creative screening strategies that increase the likelihood of identifying compounds with desired activities and provide perspective to inspire development of novel screens for the identification of first-in-class antifungals.
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