Functional neuroimaging studies of the amygdala in depression.
Functional neuroimaging studies of the amygdala in depression.
复制标题
DOI：
10.1053/scnp.2002.35219
复制
发表时间：
2002-10-01
期刊：
影响因子：
--
通讯作者：
Kim, Hackjin
中科院分区：
文献类型：
--
作者：
Whalen, Paul J;Shin, Lisa M;Kim, Hackjin
在这里，我们回顾了人类功能性神经影像学研究，表明杏仁核可能在抑郁症中发挥关键作用。我们首先回顾有关杏仁核功能的动物和人类数据。然后，我们将这些结果与正常人类杏仁核功能的神经影像学研究结果进行比较。最后，我们根据动物和人类的数据讨论了抑郁症中杏仁核的功能神经影像学研究。我们的结论是，对这种疾病的初步研究提供了杏仁核受累的证据。此外，我们认为杏仁核参与的范围可能超出了它在恐惧中的众所周知的作用，而在调节时刻到时刻的警觉性水平方面发挥了更微妙和更广泛的作用。
Here we review human functional neuroimaging studies suggesting that the amygdala may play a key role in depression. We begin by reviewing animal and human data concerning the function of the amygdala. We then compare these results with those of neuroimaging studies of normal human amygdala function. Finally, we discuss functional neuroimaging studies of the amygdala in depression in light of the animal and human data. We conclude that the initial studies of this disorder provide evidence of amygdala involvement. Furthermore, we suggest that the scope of the amygdala's involvement may go beyond its well-known role in fear to its more subtle and generalized role in modulating moment-to-moment vigilance levels.