A 3 T event-related functional magnetic resonance imaging (fMRI) study of primary and secondary gustatory cortex localization using natural tastants
A 3 T event-related functional magnetic resonance imaging (fMRI) study of primary and secondary gustatory cortex localization using natural tastants
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使用天然促味剂对初级和次级味觉皮层定位进行的 3 T 事件相关功能磁共振成像 (fMRI) 研究
DOI：
10.1007/s00234-006-0160-6
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发表时间：
2006
期刊：
影响因子：
2.8
通讯作者：
S. Sunaert
中科院分区：
文献类型：
--
作者：
M. Smits;R. Peeters;P. Hecke;S. Sunaert
已知味觉在脑岛、额叶和顶盖以及眶前皮质(次级味觉皮质)集中表达。在功能磁共振成像(FMRI)实验中，脑岛的激活已经被证实，但在眶前皮质的激活很少被发现，特别是在较高的场强(3T)下。由于大的易感性伪影，眼眶额叶皮质是一个难以用功能磁共振成像检查的区域。我们的目标是在3T时定位味觉在人类大脑皮层中的位置，特别是在眶前皮质和初级味觉皮质中。味觉刺激由柠檬汁和巧克力组成。为了可视化眼眶额叶皮质的激活，除了使用2D SENSE EPI fMRI序列对整个大脑进行成像外，还使用了专用的3D SENSE EPI fMRI序列。使用基于感知的模型对数据进行分析。结果专用的3D SENSE EPI序列成功地减少了眶前区的易感性伪影。在眼眶额叶和岛叶皮质有明显的味觉相关激活。结论眼眶额叶皮质的功能磁共振成像在3T时是可行的，使用专用序列。我们的结果证实了先前研究的发现。
IntroductionIt is known that taste is centrally represented in the insula, frontal and parietal operculum, as well as in the orbitofrontal cortex (secondary gustatory cortex). In functional MRI (fMRI) experiments activation in the insula has been confirmed, but activation in the orbitofrontal cortex is only infrequently found, especially at higher field strengths (3 T). Due to large susceptibility artefacts, the orbitofrontal cortex is a difficult region to examine with fMRI. Our aim was to localize taste in the human cortex at 3 T, specifically in the orbitofrontal cortex as well as in the primary gustatory cortex.MethodsEvent-related fMRI was performed at 3 T in seven healthy volunteers. Taste stimuli consisted of lemon juice and chocolate. To visualize activation in the orbitofrontal cortex a dedicated 3D SENSE EPI fMRI sequence was used, in addition to a 2D SENSE EPI fMRI sequence for imaging the entire brain. Data were analyzed using a perception-based model.ResultsThe dedicated 3D SENSE EPI sequence successfully reduced susceptibility artefacts in the orbitofrontal area. Significant taste-related activation was found in the orbitofrontal and insular cortices.ConclusionfMRI of the orbitofrontal cortex is feasible at 3 T, using a dedicated sequence. Our results corroborate findings from previous studies.
影响因子：
2.5
作者：
Small, DM;Voss, J;Gitelman, D
通讯作者：
Gitelman, D
品尝浓缩奎宁和糖溶液的神经相关性。
影响因子：
2.5
作者：
Zald,DavidH;Hagen,MathewC;Pardo,JoséV
通讯作者：
Pardo,JoséV