Expression levels of heat shock protein 20 decrease in parallel with tumor progression in patients with hepatocellular carcinoma.
Expression levels of heat shock protein 20 decrease in parallel with tumor progression in patients with hepatocellular carcinoma.
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DOI：
10.3892/or.17.6.1309
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发表时间：
2007-06
期刊：
影响因子：
4.2
通讯作者：
Takahiro Noda;T. Kumada;S. Takai;R. Matsushima-Nishiwaki;N. Yoshimi;E. Yasuda;Kanefusa Kato;H. Toyoda;Y. Kaneoka;A. Yamaguchi;O. Kozawa
中科院分区：
文献类型：
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作者：
Takahiro Noda;T. Kumada;S. Takai;R. Matsushima-Nishiwaki;N. Yoshimi;E. Yasuda;Kanefusa Kato;H. Toyoda;Y. Kaneoka;A. Yamaguchi;O. Kozawa
热休克蛋白（HSP） 20是一种低分子量的热休克蛋白，在平滑肌、骨骼肌和肝脏等多种组织中均有组成性表达。然而，HSP20的特性和功能尚未得到准确的了解。在本研究中，我们研究了53例肝细胞癌（HCC）切除标本中HSP20在肝细胞癌（HCC）组织与具有临床和病理特征的周围组织中的表达水平的相关性。虽然在所有53例HCC组织中均检测到HSP20，但与邻近非肿瘤组织相比，HSP20的表达水平降低。HSP20的表达水平与TNM分期（p<0.01）、有无微血管侵犯（p<0.05）、肿瘤大小（p<0.05）呈负相关。我们的研究结果强烈提示HSP20可能对人类HCC的进展起作用。
Heat shock protein (HSP) 20, a low-molecular-weight HSP, is constitutively expressed in various tissues, such as smooth muscle, skeletal muscle, and liver. However, the characteristics and function of HSP20 have not been precisely understood. In the present study, we investigated correlations of expression levels of HSP20 in hepatocellular carcinoma (HCC) tissues and the surrounding tissues with clinical and pathologic characteristics in 53 resected HCC specimens. Although HSP20 was detected in all 53 HCC tissues, the expression levels were reduced compared with those in the adjacent non-tumor tissues. The expression levels of HSP20 were inversely correlated with tumor stage by TNM classification (p<0.01), presence of microvascular invasion (p<0.05), and tumor size (p<0.05). Our findings strongly suggest that HSP20 may play a role against the progression of human HCC.