Cataract Surgery Lowers Intraocular Pressure and Medication Use in the Medication Group of the Ocular Hypertension Treatment Study.
Cataract Surgery Lowers Intraocular Pressure and Medication Use in the Medication Group of the Ocular Hypertension Treatment Study.
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白内障手术降低了眼部高血压治疗研究的药物组中的眼内压力和药物使用。
DOI：
10.1016/j.ajo.2021.07.008
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发表时间：
2022-04
影响因子：
4.2
通讯作者：
Ocular Hypertension Treatment Study group
中科院分区：
文献类型：
--
作者：
Mansberger SL;Gardiner SK;Gordon M;Kass M;Ramulu P;Ocular Hypertension Treatment Study group
确定高眼压治疗研究（OHTS）药物组中白内障摘除术后眼内压（IOP）的变化和眼部扩张药物的使用。随机临床试验数据的次要分析我们纳入了OHTS药物组的92名参与者（n=149只眼），他们在研究期间至少有一只眼睛接受了白内障手术，药物组的531名参与者（n=1004只眼）没有接受白内障手术。我们将“分割日期”定义为白内障手术组报告白内障手术的首次研究访视和对照组的第15次访视，以平衡中位访视次数。然后，我们在相对于该分割日期的访视时比较了两组。在72个月期间，白内障组和对照组之间术前和术后IOP的差异，以及眼部消肿药物的类别数量。与对照组相比，白内障手术在所有术后访视时显著减少了眼部麻醉药物的数量（平均-0.4药物，p<=.005），直至术后48个月访视。在分割日期，约23%的眼睛无药物，41%的眼睛药物负担减轻。白内障手术导致IOP降低（p<0.001），但组间IOP差异随时间推移而降低，12个月后变得不显著。治疗高眼压患者的白内障手术可持续减少眼内扩张药物的平均用量，并可短暂降低眼内压。
To determine the change in intraocular pressure (IOP), ocular hypotensive medication use after cataract extraction in the Medication Group of the Ocular Hypertension Treatment Study (OHTS). Secondary analysis of randomized clinical trial data We included 92 participants (n=149 eyes) of the OHTS Medication Group who underwent cataract surgery in at least one eye during the study, and 531 participants (n=1004 eyes) of the Medication Group who did not undergo cataract surgery. We defined the “split date” as the first study visit that cataract surgery was reported for the cataract surgery group, and the 15th visit in the control group to equalize the median number of visits. We then compared the two groups at visits relative to this split date. Difference in preoperative and postoperative IOP, and number of classes of ocular hypotensive medications between the cataract and control group over a 72 month period. Cataract surgery significantly decreased the number of ocular hypotensive medications at all postoperative visits (mean −0.4 medications, p<=.005) through the 48-month postoperative visit when compared to the control group. At the split date, approximately 23% of eyes were medication free and 41% had a reduced medication burden. Cataract surgery resulted in a decrease in IOP (p<.001), but the difference in IOP between the groups reduced over time, and became non-significant after 12 months. Cataract surgery in treated ocular hypertension patients produced sustained reductions in the average number of ocular hypotensive medications and transient reductions in intraocular pressure.
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影响因子：
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