Effects of selective excitotoxic prefrontal lesions on acquisition of nonmatching- and matching-to-place in the T-maze in the rat: differential involvement of the prelimbic-infralimbic and anterior cingulate cortices in providing behavioural flexibility
Effects of selective excitotoxic prefrontal lesions on acquisition of nonmatching- and matching-to-place in the T-maze in the rat: differential involvement of the prelimbic-infralimbic and anterior cingulate cortices in providing behavioural flexibility
复制标题
DOI：
10.1046/j.0953-816x.2000.01323.x
复制
发表时间：
2000-12-01
影响因子：
3.4
通讯作者：
Aggleton, JP
中科院分区：
文献类型：
--
作者：
Dias, R;Aggleton, JP
本研究探讨了内侧前额叶皮层及其主要分区，背前扣带（ACd）和边缘前-边缘下（PL）皮层，空间工作记忆和抑制控制过程的贡献。在实验1中，集中在ACd或PL皮层的兴奋性毒性病变并没有影响收购的非匹配放置任务在T-迷宫中的保留间隔为10秒。然而，同样的强化交替任务受损较大的前额叶病变相结合的ACd和PL皮质。在实验2中，新的动物在T型迷宫中接受了一项与位置匹配的任务，该任务使用了一条规则来对抗动物的先天偏见，以自发地交替。现在，ACd和PL皮质的离散损伤损害了获取，但方式不同。与对照组相比，PL和ACd病变的动物均因不匹配而持续了更多的会话，但只有PL动物还表现出更普遍的持续增加，反映在应用无效反应规则（例如始终右转）的进一步延长期和从匹配到不匹配的逆转缺陷中。收购的匹配到地方的任务也受损的ACd和PL皮质的联合病变。总体而言，虽然空间工作记忆过程似乎保持完整的离散前额叶病变的动物，目前的研究结果提供了强有力的证据，差异参与的前边缘-边缘下区和前扣带区在提供行为的灵活性。
The present study investigated the contributions of the medial prefrontal cortex and its major subdivisions, the dorsal anterior cingulate (ACd) and prelimbic-infralimbic (PL) cortices, to spatial working memory and inhibitory control processes. In experiment 1, excitotoxic lesions centred in the ACd or PL cortex did not affect acquisition of a nonmatching-to-place task in the T-maze with a retention interval of 10 s. However, the same reinforced alternation task was impaired by larger prefrontal lesions that combined ACd and PL cortices. In experiment 2, new animals were trained on a matching-to-place task in the T-maze that uses a rule counter to the animals' innate bias to alternate spontaneously. Now, discrete lesions of both the ACd and PL cortices impaired acquisition, but in different ways. Both animals with PL and with ACd lesions perseverated by nonmatching for more sessions than the controls, but only the PL animals also showed a more general increase in perseveration reflected in a further, extended period of applying an inefficient response rule (e.g. always turn right) and a deficit at reversing from matching to nonmatching. Acquisition of the matching-to-place task was also impaired by combined lesions of ACd and PL cortices. Overall, whilst spatial working memory processes appear to remain intact in those animals with discrete prefrontal lesions, the present findings provide strong evidence for the differential involvement of the prelimbic-infralimbic and anterior cingulate regions in providing behavioural flexibility.