The regional-dependent biaxial behavior of young and aged mouse skin: A detailed histomechanical characterization, residual strain analysis, and constitutive model
The regional-dependent biaxial behavior of young and aged mouse skin: A detailed histomechanical characterization, residual strain analysis, and constitutive model
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DOI：
10.1016/j.actbio.2019.10.020
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发表时间：
2020-01-01
影响因子：
9.7
通讯作者：
Rausch, Manuel K.
中科院分区：
文献类型：
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作者：
Meador, William D.;Sugerman, Gabriella P.;Rausch, Manuel K.
皮肤具有多种重要功能，其中许多功能取决于其机械性能。因此，由于小鼠已成为皮肤研究的宝贵模型，因此确定小鼠皮肤的机械特性非常重要。具体而言，皮肤的机械性能对于功能测试以及预后和诊断目的是重要的。此外，皮肤行为的计算机模拟正变得司空见惯，从而需要小鼠皮肤的本构行为的精确模型。到目前为止，我们对小鼠皮肤力学的知识显示出显著的差距。例如，没有将皮肤的机械特性与区域、年龄和方向相关联的综合报告。此外，小鼠皮肤的残余应变行为还没有报道。在我们目前的工作中，我们着手填补这些空白。基于组织学，2-光子显微镜，和平面双轴测试，同时准确地跟踪各种参考配置，我们报告的差异，总结构，微观组织，和本构反应的皮肤，并将这些属性转换成一个通用的真菌型超弹性本构关系的三个参考配置。我们的数据是最全面的报告，对比年轻（12周）和老年（52周）小鼠皮肤的机械性能，因此，将是有价值的基础科学作为控制数据，并提供准确的本构关系小鼠皮肤modeling.Statement的意义我们的研究结果是显着的，因为它们填补了我们的理解小鼠皮肤力学的几个空白。这是特别重要的，因为小鼠皮肤正在成为化妆品和医学科学中人类皮肤的常见和关键模型。具体来说，我们量化了小鼠皮肤的机械特性如何随年龄、位置和方向而变化。此外，我们将我们的研究结果转化为本构模型，可供其他人用于预测皮肤行为的计算机模拟。(C)2019 Acta Materialia Inc.由爱思唯尔有限公司出版。保留所有权利。
Skin fulfills several vital functions, many of which are dependent on its mechanical properties. Therefore, as mice have become an invaluable model for skin research, determining murine skin's mechanical properties is important. Specifically, skin's mechanical properties are important for functional tests as well as for prognostic and diagnostic purposes. Additionally, computational simulations of skin behavior are becoming commonplace, rendering accurate models of murine skin's constitutive behavior necessary. To date, our knowledge of mouse skin mechanics shows significant gaps. For example, there are no comprehensive reports correlating skin's mechanical properties with region, age, and direction. Moreover, mouse skin's residual strain behavior has not been reported on. In our current work, we set out to fill these gaps. Based on histology, 2-photon microscopy, and planar biaxial testing, while accurately tracking various reference configurations, we report on differences in gross structure, microstructural organization, and constitutive response of skin, and cast those properties into a versatile Fung-type hyperelastic constitutive law for three reference configurations. Our data is the most comprehensive report contrasting the mechanical properties of young (12 weeks) and aged (52 weeks) mouse skin and will, thus, be valuable to basic science as control data, and provide accurate constitutive laws for mouse skin modeling.Statement of significanceOur findings are significant as they fill several gaps in our understanding of mouse skin mechanics. This is particularly important as mouse skin is becoming a frequent and critical model of human skin for cosmetic and medical science. Specifically, we quantified how mechanical properties of mice skin vary with age, with location, and with direction. Additionally, we cast our findings into constitutive models that can be used by others for predictive computer simulations of skin behavior. (C) 2019 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.