Detection of gadolinium deposition in cortical bone with ultrashort echo time T(1)mapping: an ex vivo study in a rabbit model
Detection of gadolinium deposition in cortical bone with ultrashort echo time T(1)mapping: an ex vivo study in a rabbit model
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用超短回波时间 T(1) 映射检测皮质骨中的钆沉积：兔模型的离体研究
DOI：
10.1007/s00330-020-07258-x
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发表时间：
2021
影响因子：
5.9
通讯作者：
Feng Yanqiu
中科院分区：
文献类型：
--
作者：
Zhao Kaixuan;Li Shisi;Yi Peiwei;Guo Yihao;Yu Qinqin;Zhu Cuiling;Feng Qianjin;Du Jiang;Zhang Xiaodong;Feng Yanqiu
目的探讨超短回波时间(UTE)T1地形图非侵入性评价Gd在皮质骨中沉积的能力。方法28只新西兰大白兔(雄性，3.0~3.5 kg)随机分为对照组、大环组、大环组和线性组(每组7只)，分别给予生理盐水、0.3 mmol/kg体重的加多布曲尔、0.9 mmol/kg体重的加多布曲尔和0.3 mmol/kg体重的加多布曲明，连续5天，共4周。在随后的4周恢复后，处死动物，取胫骨。在7T动物扫描仪上采用UTE实际翻转角成像和可变重复时间相结合的方法测量皮质骨的T1值。用电感耦合等离子体质谱(ICPMS)测定骨皮质中Gd的浓度。结果低剂量大环组(329.2±21.0ms)、高剂量组(316.8±21.7ms)、线性组(296.8±24.1ms，p<；0.001)骨T1值显著低于对照组(356.3±19.4ms)。电感耦合等离子体质谱测得对照组、低剂量大环组、高剂量大环组和线性大环组的Gd含量分别为0.04±0.02μg/g、2.60±0.48μg/g、4.95±1.17μg/g和13.62±1.55μg/g。结论UTE T1标测有可能对GbCA治疗后皮质骨中Gd沉积进行无创性评估。要点：无论是线性给药还是大周期给药，骨组织中Gd沉积相关的T1值均发生了变化。·R1弛豫法与皮质骨中Gd浓度密切相关。·UTE T1标测为无创监测Gd在皮质骨中沉积提供了一个潜在的工具。
ObjectivesTo investigate the capacity of ultrashort echo time (UTE) T1mapping to non-invasively assess gadolinium deposition in cortical bone after gadolinium-based contrast agent (GBCA) administration.MethodsTwenty-eight New Zealand rabbits (male, 3.0–3.5 kg) were randomly allocated into control, macrocyclic, high-dose macrocyclic, and linear GBCA groups (n= 7 for each group), and respectively given daily doses of 0.9 ml/kg bodyweight saline, 0.3 mmol/kg bodyweight gadobutrol, 0.9 mmol/kg bodyweight gadobutrol, and 0.3 mmol/kg bodyweight gadopentetate dimeglumine for five consecutive days per week over a period of 4 weeks. After a subsequent 4 weeks of recovery, the rabbits were sacrificed and their tibiae harvested. T1value of cortical bone was measured using a combination of UTE actual flip angle imaging and variable repetition time on a 7T animal scanner. Gadolinium concentration in cortical bone was measured using inductively coupled plasma mass spectrometry (ICP-MS). Pearson’s correlation between R1value (R1= 1/T1) and gadolinium concentration in cortical bone was assessed.ResultsBone T1values were significantly lower in the lower-dose macrocyclic (329.2 ± 21.0 ms,p< 0.05), higher-dose macrocyclic (316.8 ± 21.7 ms,p< 0.01), and linear (296.8 ± 24.1 ms,p< 0.001) GBCA groups compared with the control group (356.3 ± 19.4 ms). Gadolinium concentrations measured by ICP-MS in the control, lower-dose macrocyclic, higher-dose macrocyclic, and linear GBCA groups were 0.04 ± 0.02 μg/g, 2.60 ± 0.48 μg/g, 4.95 ± 1.17 μg/g, and 13.62 ± 1.55 μg/g, respectively. There was a strong positive correlation between R1values and gadolinium concentrations in cortical bone (r= 0.73,p< 0.001).ConclusionsThese results suggest that UTE T1mapping has the potential to provide a non-invasive assessment of gadolinium deposition in cortical bone following GBCA administration.Key Points• Changes in T1value related to gadolinium deposition were found in bone after both linear and macrocyclic GBCA administrations.• R1relaxometry correlates strongly with gadolinium concentration in cortical bone.• UTE T1mapping provides a potential tool for non-invasively monitoring gadolinium deposition in cortical bone.