Uterine molecular responses to bisphenol A treatment before and after decidual induction in pseudopregnant rats.
Uterine molecular responses to bisphenol A treatment before and after decidual induction in pseudopregnant rats.
复制标题
假孕大鼠蜕膜诱导前后子宫分子对双酚 A 治疗的反应。
DOI：
10.1078/1438-4639-00115
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发表时间：
2002
影响因子：
6
通讯作者：
Lemelle,Chad
中科院分区：
文献类型：
--
作者：
Spencer,Fitzgerald;Chi,Limen;Zhu,Ming-Xia;Nixon,Everett;Lemelle,Chad
研究结果表明，双酚A对假孕Sprague-Dawley大鼠蜕膜瘤生长的弱雌激素作用（每日皮下给药200 mg/kg，连续4天，在假孕第4天发生的蜕膜诱导之前或之后给药）与子宫的激素状态在功能上相关。而双酚A在前蜕膜，雌激素相关时期显示子宫营养作用，它抑制蜕膜生长和孕酮分泌在后蜕膜，孕酮为主的时期。双酚A对子宫蜕膜生长的雌激素作用与雌激素受体结合位点和mRNA表达水平的降低以及血清雌二醇浓度的变化无关。BPA的作用似乎被孕酮拮抗。
The results of the study demonstrate that the weak estrogenic action of bisphenol A (a daily subcutaneous dose of 200mg/kg on 4 consecutive days, administered before or after decidual induction that occurs on day 4 of pseudopregnancy) on deciduoma growth in pseudopregnant Sprague-Dawley rats, was functionally associated with the hormonal status of the uterus. Whereas bisphenol A displayed uterotrophic action during the pre-decidual, estrogen related period, it inhibited decidual growth and progesterone secretion during the post-decidual, progesterone-dominated period. The estrogenic action of bisphenol A on uterine decidual growth was not correlated with the reduced levels of estrogen receptor binding sites and mRNA expression, nor the unchanged serum estradiol concentrations. BPA action appeared to be antagonized by progesterone.