Intelligent systems and technology for integrative and predictive medicine: an ACP approach
Intelligent systems and technology for integrative and predictive medicine: an ACP approach
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综合和预测医学的智能系统和技术：ACP 方法
DOI：
10.1145/2438653.2438667
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发表时间：
2013
影响因子：
5
通讯作者：
Wong Pak Kin
中科院分区：
文献类型：
--
作者：
Wang Fei-Yue;Wong Pak Kin
医学的主要目标之一是通过对治疗程序的效果和益处的严格评估来确定和实施对患者的最佳治疗。然而，生理和病理网络在时间和长度尺度上跨越数量级的固有复杂性代表了确定患者有效治疗方法的根本障碍。在这里，我们主张一种新的方法，称为基于ACP的方法，它结合了人工（社会），计算（实验）和并行（执行）的方法，在智能系统和技术中用于综合和预测医学，或者更一般地说，精确医学和智能健康管理。人工社会的出现，收集临床相关的信息，在药理学和治疗学提供了一个有前途的平台，组织和实验复杂的生理系统，走向综合医学。计算实验的能力，分析不同的，互动的系统，如主机的机制，病理途径，和治疗策略，以及其他因素，使用人工系统，将使控制和管理，通过并行执行的真实的和arrhythmic系统同时在综合医学的背景下。在医生、工程师和科学家之间的密切合作下，这一框架在整合医学中的发展将导致个人、主动和精确的预防和预测实践，包括合理的组合治疗、适应性治疗和以患者为导向的疾病管理。
One of the principal goals in medicine is to determine and implement the best treatment for patients through fastidious estimation of the effects and benefits of therapeutic procedures. The inherent complexities of physiological and pathological networks that span across orders of magnitude in time and length scales, however, represent fundamental hurdles in determining effective treatments for patients. Here we argue for a new approach, called the ACP-based approach, that combinesartificial (societies), computational (experiments), and parallel (execution)methods in intelligent systems and technology for integrative and predictive medicine, or more generally, precision medicine and smart health management. The advent of artificial societies that collect the clinically relevant information in prognostics and therapeutics provides a promising platform for organizing and experimenting complex physiological systems toward integrative medicine. The ability of computational experiments to analyze distinct, interactive systems such as the host mechanisms, pathological pathways, and therapeutic strategies, as well as other factors using the artificial systems, will enable control and management through parallel execution of real and arficial systems concurrently within the integrative medicine context. The development of this framework in integrative medicine, fueled by close collaborations between physicians, engineers, and scientists, will result in preventive and predictive practices of a personal, proactive, and precise nature, including rational combinatorial treatments, adaptive therapeutics, and patient-oriented disease management.