Side-to-Side Jejunoileal Anastomosis plus Proximal Loop Ligation: a Novel Intestinal Bypass Model for Diabetic Rats
Side-to-Side Jejunoileal Anastomosis plus Proximal Loop Ligation: a Novel Intestinal Bypass Model for Diabetic Rats
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DOI：
10.1007/s11695-013-1129-2
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发表时间：
2013
期刊：
影响因子：
2.9
通讯作者：
Jinyuan Duan;Lianwen Yuan;Jianping Zhou
中科院分区：
文献类型：
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作者：
Jinyuan Duan;Lianwen Yuan;Jianping Zhou
致编辑：在20世纪60年代末和70年代初，空回肠旁路术（JIB）经常作为大面积肥胖症的减肥手术选择;然而，由于该手术的严重并发症（包括严重营养不良、肝衰竭和盲袢综合征），该技术在20世纪80年代中期已经过时[1]。端侧空回肠吻合术需要横断空肠，从而将空肠支与自体起搏器分开。因此，异位起搏器在旁路肢体的中间产生，并且以低得多的频率起搏，偶尔以口腔方向起搏，这导致营养物质回流到旁路肢体[2]和肠套叠[3]。然而，JIB程序仍在某些医疗中心进行修改。最近的动物和临床研究表明，50%至60%的肠旁路术或切除术可以解决链脲佐菌素（STZ）诱导的糖尿病大鼠的糖尿病[4]，并恢复非肥胖或轻度肥胖2型糖尿病患者的葡萄糖稳态[5]。
To the Editor: In the late 1960s and early 1970s, jejunoileal bypass (JIB) was performed frequently as a bariatric surgical option for massive obesity; however, this technique had become obsolete by the mid-1980s due to the serious complications of the procedure, which include severe malnutrition, liver failure, and blind loop syndrome [1]. The end-to-side jejunoileal anastomosis necessitates transection of the jejunum, thus dividing the jejunal limb from the native pacemaker. As a result, the ectopic pacemakers are generated in the middle of the bypassed limb and are paced at a much lower frequency and, occasionally, in an oral direction, which leads to the reflux of nutrients into the bypassed limb [2] and intestinal intussusception [3]. However, the JIB procedure is still being performed with modifications at certain medical centers. Recent animal and clinical studies have indicated that 50 to 60% of intestinal bypass or resection procedures can resolve diabetes in streptozotocin (STZ)-induced diabetic rats [4] and restore glucose homeostasis in nonobese or mildly obese type 2 diabetic patients [5].