ACUTE MYOCARDIAL-INFARCTION IN A YOUNG BOY WITH NEPHROTIC SYNDROME - A CASE-REPORT AND REVIEW OF THE LITERATURE
ACUTE MYOCARDIAL-INFARCTION IN A YOUNG BOY WITH NEPHROTIC SYNDROME - A CASE-REPORT AND REVIEW OF THE LITERATURE
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DOI：
10.1007/bf00866337
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发表时间：
1994-06-01
影响因子：
3
通讯作者：
ORCHARD, TJ
中科院分区：
文献类型：
--
作者：
HOPP, L;GILBOA, N;ORCHARD, TJ
一名7岁男孩，因微小病变导致类固醇无反应性肾病综合征5年，出现急性心肌梗死。血管造影提示右冠状动脉起始部和中部存在夹层动脉粥样硬化斑块，以及回旋支中部存在病变。该儿童有长期的极端高胆固醇血症和高胆固醇血症病史，沿着载脂蛋白-E 4/3表型。母亲也有载脂蛋白-E 4/3表型，有轻度高胆固醇血症。该病例表明，患有长期肾病综合征的儿童，即使有轻度高脂血症家族倾向，也可能增加缺血性心血管事件的风险。本文就肾病综合征与缺血性心脏病发病的关系作一综述。
A 7-year-old boy with a 5-year history of steroid-unresponsive nephrotic syndrome due to minimal change disease presented with acute myocardial infarction. Angiography was suggestive of a dissected atherosclerotic plaque at the initial and mid portions of the right coronary artery, as well as a lesion in the mid portion of the circumflex artery. The child had a long history of extreme hypercholesterolemia and hypertriglyceridemia, along with apolipoprotein-E 4/3 phenotype. The mother, who also has apolipoprotein-E 4/3 phenotype, has mild hypercholesterolemia. The case suggests that children with long-lasting nephrotic syndrome and even mild familial propensity for hyperlipidemia may be at increased risk for ischemic cardiovascular events. The Literature is reviewed regarding the relationship between nephrotic syndrome and the incidence of ischemic heart disease.