Neonatal thymectomy results in a repertoire enriched in T cells deleted in adult thymus.
Neonatal thymectomy results in a repertoire enriched in T cells deleted in adult thymus.
复制标题
DOI：
10.1126/science.2788921
复制
发表时间：
1989-08
期刊：
影响因子：
56.9
通讯作者：
H. Smith;I. Chen;R. Kubo;KS K Tung
中科院分区：
文献类型：
--
作者：
H. Smith;I. Chen;R. Kubo;KS K Tung
在B6AF1小鼠中，在其抗原受体中使用Vβ11阳性(而不是Vβ6阳性或Vβ8阳性)片段的T淋巴细胞在胸腺和外周淋巴组织中大大减少，这很可能是克隆缺失的结果。出生后1~4天切除胸腺的B6AF1小鼠成年淋巴结中Vβ11阳性细胞的相对数量是正常小鼠的10倍。此外，在B6AF1小鼠出生的前10天，胸腺和脾中很容易检测到成熟的Vβ11阳性T细胞。因此，新生儿胸腺切除可以维持出生后早期生命的受体谱系，这与随后器官特异性自身免疫性疾病的发生有关。
In B6AF1 mice, T lymphocytes that use the V beta 11-positive (and not V beta 6-positive or V beta 8-positive) segment in their receptor for antigen are greatly reduced in the thymus and peripheral lymphoid tissues, most likely as a result of clonal deletion. The relative number of V beta 11-positive cells in adult lymph nodes was ten times as high in B6AF1 mice thymectomized 1 to 4 days after birth as in normal mice. Moreover, for the first 10 days of life of B6AF1 mice, mature V beta 11-positive T cells were readily detected in the thymus and spleen. Thus neonatal thymectomy results in the maintenance of the receptor repertoire of early postnatal life, and this correlates with the subsequent development of organ-specific autoimmune diseases.