Psoriasis associated with HCV and exacerbated by interferon alpha:: Complete clearance with acitretin during interferon alpha treatment for chronic active hepatitis
Psoriasis associated with HCV and exacerbated by interferon alpha:: Complete clearance with acitretin during interferon alpha treatment for chronic active hepatitis
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DOI：
10.1159/000018447
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发表时间：
2000-01-01
期刊：
影响因子：
3.4
通讯作者：
Bükülmez, G
中科院分区：
文献类型：
--
作者：
Erkek, E;Karaduman, A;Bükülmez, G
牛皮癣是一种病因不明的炎症性皮肤病。许多观察表明，T细胞在疾病的发病机制中起重要作用。感染与银屑病的病因有关;最有力的证据是链球菌感染[1]。然而，T细胞活化抗原可以来自于远处或局部病毒感染[2]。丙型肝炎病毒（HCV）是肠道外传播的非甲非乙型病毒性肝炎的主要病原体。据报道，HCV感染与肝脏以外的各种器官（包括皮肤）的疾病有关[3]。有报告称银屑病发生在慢性HCV感染的情况下[4，5]。
Psoriasis is an inflammatory skin disease of unknown etiology. Many observations indicate that T cells play an important role in the pathogenesis of the disease. Infections have been implicated in the etiology of psoriasis; the strongest evidence is for streptococcal infections [1]. However, T-cell-activating antigens could be derived from distant or local viral infections [2].Hepatitis C virus (HCV) is the main causative agent of parenterally transmitted non-A, non-B viral hepatitis. HCV infection has been reported to be associated with disorders of various organs other than the liver, including the skin [3]. There are reports of psoriasis occurring in the setting of chronic HCV infection [4, 5].