Dose-response relationship between ischemic heart disease mortality and long-term arsenic exposure
Dose-response relationship between ischemic heart disease mortality and long-term arsenic exposure
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DOI：
10.1161/01.atv.16.4.504
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发表时间：
1996-04-01
影响因子：
8.7
通讯作者：
Tai, TY
中科院分区：
文献类型：
--
作者：
Chen, CJ;Chiou, HY;Tai, TY
无机砷对心血管的影响已被证实，但缺血性心脏病（ISHD）和长期砷暴露之间的剂量反应关系仍有待阐明。本文分析了台湾地区60个砷中毒流行村1973 ~ 1986年间居民因砷中毒而死亡的情况，以探讨其与饮水中砷浓度的关系。基于1.355915人-年和217例ISHD死亡，对于生活在饮用水中砷浓度中位数为3.5%的村庄的居民，从出生到79岁的累积ISHD死亡率分别为3.4%、3.5%、4.7%和6.6%。
The cardiovascular effects of inorganic arsenic have been documented, but the dose-response relationship between ischemic heart disease (ISHD) and long-term arsenic exposure remains to be elucidated. Mortality rates from ISHD among residents in 60 villages of the area in Taiwan with endemic arseniasis from 1973 through 1986 were analyzed to examine their association with arsenic concentration in drinking water. Based on 1.355 915 person-years and 217 ISHD deaths, the cumulative ISHD mortalities from birth to age 79 years were 3.4%, 3.5%, 4.7%, and 6.6%, respectively, for residents who lived in villages in which the median arsenic concentrations in drinking water were