Norian SRS cement augmentation in hip fracture treatment. Laboratory and initial clinical results.
Norian SRS cement augmentation in hip fracture treatment. Laboratory and initial clinical results.
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Norian SRS 骨水泥增强髋部骨折治疗。
DOI：
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发表时间：
1998
影响因子：
4.2
通讯作者：
R. Poser
中科院分区：
文献类型：
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作者：
S. Goodman;T. Bauer;D. Carter;P. Casteleyn;S. Goldstein;R. Kyle;S. Larsson;C. Stankewich;M. Swiontkowski;A. Tencer;D. Yetkinler;R. Poser
骨质量、骨折初始移位、骨折粉碎严重程度、骨折复位的准确性、内固定装置的放置是影响内固定稳定性的重要因素。新型高强度骨水泥易改建和置换固定髋部骨折，可能会改善髋部骨折的临床疗效。NORIAN SRS是一种可注射的快速固化水泥，可在体内固化，形成具有高抗压强度(55兆帕)的骨传导碳酸盐磷灰石，其化学和物理特性类似于骨的矿物相。它可以作为一种间隙填充内固定装置，促进松质骨区有缺陷和/或骨折的骨的几何重建、载荷转移和愈合。此外，该粘固剂还可以提高传统固定装置的机械握持强度。使用这种材料可能会提高骨折的稳定性，在骨折愈合过程中保留解剖结构，改善髋关节功能，从而获得更好的临床结果。活体动物研究显示了该材料的生物相容性，身体研究显示了其用于髋部骨折的生物力学优势。初步的临床经验(52例股骨颈骨折和39例粗隆间骨折)表明，这种创新的骨水泥在治疗髋部骨折中具有潜在的临床应用价值。
Bone quality, initial fracture displacement, severity of fracture comminution, accuracy of fracture reduction, and the placement of the internal fixation device are important factors that affect fixation stability. New high strength cements that are susceptible to remodeling and replacement for fracture fixation may lead to improved clinical outcome in the treatment of hip fractures. Norian SRS is an injectable, fast setting cement that cures in vivo to form an osteoconductive carbonated apatite of high compressive strength (55 MPa) with chemical and physical characteristics similar to the mineral phase of bone. It can be used as a space filling internal fixation device to facilitate the geometric reconstruction, load transfer, and healing of bone with defects and/or fractures in regions of cancellous bone. Furthermore, this cement can improve the mechanical holding strength of conventional fixation devices. Use of this material potentially could improve fracture stability, retain anatomy during fracture healing and improve hip function, thus achieving better clinical outcomes. In vivo animal studies have shown the material's biocompatibility, and cadaveric studies have shown the biomechanical advantage of its use in hip fractures. Initial clinical experience (in 52 femoral neck fractures and 39 intertrochanteric fractures) showed the potential clinical use of this innovative cement in the treatment of hip fractures.