DUCTAL BUDDING AND BRANCHING PATTERNS IN THE DEVELOPING PROSTATE
DUCTAL BUDDING AND BRANCHING PATTERNS IN THE DEVELOPING PROSTATE
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DOI：
10.1016/s0022-5347(17)35273-4
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发表时间：
1994-05-01
影响因子：
6.6
通讯作者：
DIDIO, LJA
中科院分区：
文献类型：
--
作者：
TIMMS, BG;MOHS, TJ;DIDIO, LJA
通过连续切片重建和计算机辅助三维分析研究了前列腺的发育。对大鼠、小鼠和人类的导管出芽情况进行比较，发现其模式符合共同的发育特征。从泌尿生殖窦发出进入周围尿道周围间质的腹侧、外侧和背侧上皮芽，遵循腹 - 背轴和头 - 尾轴。随后的分支形态发生与特定的间质凝聚有关。这些出芽模式与啮齿动物前列腺的成年叶结构密切相关。在人类胎儿中，前列腺导管出芽呈现出与当前分区解剖学概念相符的模式。
Development of the prostate was studied by serial section reconstruction and computer-assisted three-dimensional analysis. A comparison of ductal budding in species of rat and mouse and the human revealed patterns consistent with common developmental characteristics. Ventral, lateral and dorsal lines of epithelial buds, which emanated from the urogenital sinus into the surrounding periurethral mesenchyme, followed ventro-dorsal and cranio-caudal axes. Subsequent branching morphogenesis was associated with specific mesenchymal condensations. These patterns of budding were closely related to the adult lobe architecture in the rodent prostate. In the human fetus, prostate ductal budding exhibited patterns compatible with the current concept of zonal anatomy.