Unraveling neuroHIV in the Presence of Substance Use Disorders.
Unraveling neuroHIV in the Presence of Substance Use Disorders.
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解开药物使用障碍中的神经艾滋病毒。
DOI：
10.1007/s11481-020-09967-y
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发表时间：
2020
期刊：
影响因子：
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通讯作者：
Chang,Linda
中科院分区：
文献类型：
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作者：
Lin,Yu;He,JohnnyJ;Sorensen,Roger;Chang,Linda
本特刊包含10篇特邀评论论文，这些论文强调并扩展了NIDA在2019年第25届神经免疫药理学学会会议上主办的研讨会“在物质使用障碍的情况下解开神经艾滋病”的演讲。这些论文所涵盖的主题侧重于药物使用障碍与艾滋病毒感染对免疫系统和神经发病机制的相互作用、叠加或协同作用。这些论文综述了四类滥用物质（阿片类药物、烟草、兴奋剂和大麻）以及共病HIV感染（包括HIV蛋白模型、HIV转基因啮齿动物模型和SIV）如何进一步影响调节失调的多巴胺能和免疫系统，以及随后的神经发病机制和行为障碍（称为HIV相关神经障碍（HAND））。这些综述提供了关于这些成瘾物质和HIV中的每一种如何单独或共同在细胞、分子和系统水平上影响免疫系统以及随后的临床和行为结果的详细背景知识。作者还指出了当前疾病模型和方法中的差距，困惑或限制，并提出了未来的研究方向。
This special issue contains 10 invited review papers that highlighted and extended the presentations at the NIDA-sponsored workshop “Unraveling NeuroAIDS in the Presence of Substance Use Disorders”at the 25th Society on NeuroImmune Pharmacology conference in 2019. The topics covered by these papers focused on the interactive, additive or synergistic effects of substance use disorders (SUD) with HIV infection on the immune system and on neuropathogenesis. These papers reviewed four categories of substances of abuse (opioids, tobacco, stimulants, and cannabis) and how comorbid HIV infection (including models with HIV proteins, HIV transgenic rodent models and SIV) might further impact the dysregulated dopaminergic and immune systems, and the subsequent neuropathogenesis and behavioral disorders known as HIV-associated neurological disorders (HAND). These reviews provided detailed background knowledge regarding how each of these addictive substances and HIV individually or collectively affected the immune system at the cellular, molecular and system levels, and the subsequent clinical and behavioral outcomes. The authors also identified gaps, confounds or constraints in the current disease models and approaches, and proposed future research directions.