Structural comparison of yeast and human intra-mitochondrial lipid transport systems.
Structural comparison of yeast and human intra-mitochondrial lipid transport systems.
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DOI：
10.1042/bst20150264
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发表时间：
2016-04
影响因子：
3.9
通讯作者：
X. Miliara;S. Matthews
中科院分区：
文献类型：
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作者：
X. Miliara;S. Matthews
线粒体依赖于严格控制的磷脂供应。相关进化和淋巴相关蛋白(PRERI)/Ups1家族及其线粒体伴侣蛋白[TP53调节的凋亡抑制因子1(TRIAP1)/MDm35]代表了一种独特的异二聚体脂质转移系统，该系统从酵母到人类在进化上是保守的。本文对目前人和酵母体系的X射线晶体结构进行了比较和讨论，并对Preli/Ups1系统的机制有了新的认识。
Mitochondria depend on a tightly regulated supply of phospholipids. The protein of relevant evolutionary and lymphoid interest (PRELI)/Ups1 family together with its mitochondrial chaperones [TP53-regulated inhibitor of apoptosis 1 (TRIAP1)/Mdm35] represents a unique heterodimeric lipid-transfer system that is evolutionary conserved from yeast to man. Recent X-ray crystal structures of the human and yeast systems are compared and discuss here and shed new insight into the mechanism of the PRELI/Ups1 system.