Association of plasma apolipoprotein Clll, high sensitivity C-reactive protein and tumor necrosis factor-α contributes to the clinical features of coronary heart disease in Li and Han ethnic groups in China
Association of plasma apolipoprotein Clll, high sensitivity C-reactive protein and tumor necrosis factor-α contributes to the clinical features of coronary heart disease in Li and Han ethnic groups in China
复制标题
血浆载脂蛋白CIII、超敏C反应蛋白和肿瘤坏死因子-α的关联有助于中国黎族和汉族冠心病的临床特征
DOI：
10.1186/s12944-018-0830-5
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发表时间：
2018-07-27
影响因子：
4.5
通讯作者：
Liu, Yueli
中科院分区：
文献类型：
--
作者：
Chen, Lin;Sun, Minzeng;Liu, Yueli
背景：载脂蛋白油（apoCIII）是冠心病（CHD）的独立危险因素。在这项研究中，我们调查了血浆载脂蛋白C Ⅲ，超敏C反应蛋白和肿瘤坏死因子-α水平之间的关联和他们的作用，在中国的黎族和汉族冠心病的临床特征。方法：一个队列的474名参与者（238例动脉粥样硬化患者和236名健康对照）从黎族和汉族。采用SPSS 20.0软件分析冠心病各亚组的血脂谱、血浆apoCIII、TNF-α、hs-CRP的变化及其对冠心病的影响。采用卡方检验、t检验、Kruskal-Wallis或Wilcoxon-Mann-Whitney检验、Pearson或斯皮尔曼相关性检验和多元非条件Logistic回归分析冠心病各亚组的血脂谱、血浆apoCIII、TNF-α、hs-CRP的变化及其对冠心病的影响。与健康对照组相比，CHD患者的收缩压、舒张压、空腹血糖（FBS）、TG、TC、LDL-C、apoB、Lp（a）升高（P< 0.05，TC和Lp（a）; P < 0.01，FBS、TG、LDL-C、apoB），HDL-C和apoAl降低（P < 0.05）。冠心病患者血浆apoCIII、TNF-α和hs-CRP水平均高于正常对照组，（16.77 ± 5.98 mg/dL vs 10.91 ± 4.97 mg/dL; 17.23 = 6.34 pg/mL vs 9.49 +/- 3.88 pg/mL，955 +/- 7.32 mg/L vs 2 14+ 1 56 mg/L，在黎族和汉族人群中获得了相同的模式（16.46 = 6.08 mg/dL vs 11.72 +/- 5.16 mg/dL;黎族人群：15.71 +/- 5.52 pg/mL vs 9.74 +/- 4.31 pg/mL，8.21 +/- 7.09 mg/L vs 2.15 +/- 1.51 mg/L; 17.05 +/- 5.90 mg/dL vs 10.07 +/- 4.63 mg/dL; 18.59 +/- 6.73 pg/mL vs 9.23 +/- 3. 38 pg/mL; 10.75 ± 7.44 mg/L vs 2.12 ± 1.63 mg/L; P < 0.01）。稳定型心绞痛、不稳定型心绞痛和急性心肌梗死（AMI）患者血浆apoCIII、TNF-α和hs-CRP水平的配对比较显示差异有统计学意义（P < 0.01），而轻度、中度和重度狭窄患者血浆apoCIII、TNF-α和hs-CRP水平差异无统计学意义（P >0.05）。血浆apoCIII、TNF-α和hs-CRP与冠心病的发生发展有关冠心病组与对照组比较，OR值分别为2.554，7.252，6.035，P < 0.01 apoCIII与TNF-α、apoCIII与hs-CRP、TNF-α与hs-CRP的相关系数分别为r= 0.425、r = 0.319、r = 0.400，P < 0.01。中国黎族和汉族人群血浆apoCIII、hs-CRP和TNF-α与不利的血脂谱相互作用，共同构成CHD伴稳定型心绞痛、不稳定型心绞痛和AMI的临床特征。
Background: Apolipoprotein Oil (apoCIII) is an independent risk for coronary heart disease (CHD). In this study, we investigated the associations among plasma apoCIII, hs-CRP and TNF-alpha levels and their roles in the clinical features of CHD in the Li and Han ethnic groups in China.Methods: A cohort of 474 participants was recruited (238 atherosclerotic patients and 236 healthy controls) from the Li and Han ethnic groups. Blood samples were obtained to evaluate apoCIII, TNF-alpha, hs-CRP and lipid profiles Chi-squared, t-tests, and Kruskal-Wallis or Wilcoxon-Mann-Whitney tests, Pearson or Spearman correlation tests and multiple unconditional logistic regression were employed to analyze lipid profiles and variations in plasma apoCIII, TNF-alpha, hs-CRP in subgroups of CHD and their contributions to CHD using SPSS version 20.0 software.Results: Compared to healthy participants, unfavorable lipid profiles were identified in CHD patients with enhanced systolic pressure, diastolic pressure, fasting blood sugar (FBS), TG, TC, LDL-C, apoB, Lp(a) (P< 0.05, TC and Lp(a); P < 0.01, FBS, TG, LDL-C, apoB); and lower HDL-C and apoAl (P < 0.05). Plasma apoCIII, TNF-alpha and hs-CRP levels were higher in CHD individuals (16.77 +/- 5.98 mg/dL vs 10.91+4.97 mg/dL; 17.23 = 6.34 pg/mL vs 9.49 +/- 3.88 pg/mL, 955 +/- 7.32 mg/L vs 2 14+ 1 56 mg/L, P< 001 vs healthy participants) Identical patterns were obtained in the Li and Han groups (16.46 = 6.08 mg/dL vs 11.72 +/- 5.16 mg/dL; 15.71 +/- 5.52 pg/mL vs 9.74 +/- 4.31 pg/mL, 8.21 +/- 7.09 mg/L vs. 2.15 +/- 1.51 mg/L in Li people; 17.05 +/- 5.90 mg/dL vs. 10.07 +/- 4.63 mg/dL; 18.59 +/- 6.73 pg/mL vs 9.23 +/- 3. 38 pg/mL; 10.75 +/- 7.44 mg/L vs 2.12 +/- 1.63 mg/L in Han people; P < 0.01). Paired comparisons of subgroups with stable angina, unstable angina, and acute myocardial infarction (AMI) revealed significant variation in plasma levels of apoCIII, TNF-alpha and hs-CRP (P < 0.01), but not among subgroups with mild, moderate and severe stenosis (P >0.05). Plasma apoCIII, TNF-alpha and hs-CRP contributed to the development of CHD (OR = 2.554, 7.252, 6.035, P < 0.01) with paired correlations in CHD patients (apoCIII vs TNF-alpha, r= 0.425, apoCIII vs hs-CRP, r = 0.319, TNF-alpha vs hs-CRP, r = 0.400, P < 0.01).Conclusions: Association among plasma apoCIII, hs-CRP and TNF-alpha interacts with unfavorable lipid profiles to contiribute to the clinical features of CHD with stable angina, unstable angina, and AMI in the Li and Han ethnic groups in China.