Real-Time Transcranial Histotripsy Treatment Localization and Mapping Using Acoustic Cavitation Emission Feedback.
Real-Time Transcranial Histotripsy Treatment Localization and Mapping Using Acoustic Cavitation Emission Feedback.
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使用声空化发射反馈进行实时经颅组织解剖治疗定位和绘图。
DOI：
10.1109/tuffc.2020.2967586
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Xu,Zhen
中科院分区：
文献类型：
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作者：
Sukovich,JonathanR;Macoskey,JonathanJ;Lundt,JonathanE;Gerhardson,TylerI;Hall,TimothyL;Xu,Zhen
在组织破坏治疗期间产生的空化事件产生可以通过颅骨检测到的大的声空化发射（ACE）信号。本文研究了使用这些ACE信号的可行性，获得使用500 kHz，256元件半球形histotripsy换能器的元素作为接收器，定位和地图的空化活动在真实的时间通过人的颅骨在经颅histotripsy治疗。发现在本研究中使用ACE反馈信号预测的所产生的空化事件的位置精确到通过光学成像检测到的质量中心的<1.5 mm内，并且发现在%的情况下位于所产生的空化事件的测量体积内。定位结果被观察到偏向于组织摧毁阵列的焦前方向和朝向其横向原点，但仅受到焦点转向位置的微弱影响。在低脉冲重复频率（1-10 Hz）下，观察到颅骨和治疗脉冲重复频率（PRF）的选择都会影响定位结果的准确性，但在较高的脉冲重复频率（≥10 Hz）下，定位准确性稳定。测试的定位算法体外，治疗牛脑样本内安装的头盖骨，显示良好的协议之间的ACE反馈产生的治疗地图和脑样本的治疗体积的形态特征。实验期间的定位是在真实的时间内实现的，用于以高达70 Hz的速率递送的脉冲，但基准测试表明定位算法是可扩展的，这表明更高的速率是可能的，具有更强大的硬件。这篇文章的结果证明了使用ACE反馈信号定位和映射组织碎石术期间经颅产生的空化事件的可行性。这种能力具有极大地简化经颅组织摧毁术治疗的潜力，因为它可以提供用于真实的实时监测和定位经颅组织摧毁术治疗的非基于MRI的方法。
Cavitation events generated during histotripsy therapy generate large acoustic cavitation emission (ACE) signals that can be detected through the skull. This article investigates the feasibility of using these ACE signals, acquired using the elements of a 500-kHz, 256-element hemispherical histotripsy transducer as receivers, to localize and map the cavitation activity in real time through the human skullcap during transcranial histotripsy therapy. The locations of the generated cavitation events predicted using the ACE feedback signals in this study were found to be accurate to within <1.5 mm of the centers of masses detected by optical imaging and found to lie to within the measured volumes of the generated cavitation events in% of cases. Localization results were observed to be biased in the prefocal direction of the histotripsy array and toward its transverse origin but were only weakly affected by focal steering location. The choice of skullcap and treatment pulse repetition frequency (PRF) were both observed to affect the accuracy of the localization results in the low PRF regime (1–10 Hz), but the localization accuracy was seen to stabilize at higher PRFs (≥10 Hz). Tests of the localization algorithmin vitro, for treatment delivered to a bovine brain sample mounted within the skullcap, revealed good agreement between the ACE feedback-generated treatment map and the morphological characteristics of the treated volume of the brain sample. Localization during experiments was achieved in real time for pulses delivered at rates up to 70 Hz, but benchmark tests indicate that the localization algorithm is scalable, indicating that higher rates are possible with more powerful hardware. The results of this article demonstrate the feasibility of using ACE feedback signals to localize and map transcranially generated cavitation events during histotripsy. Such capability has the potential to greatly simplify transcranial histotripsy treatments, as it may provide a non-MRI-based method for monitoring and localizing transcranial histotripsy treatments in real time.