A new absorbable suture.
A new absorbable suture.
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DOI：
10.1002/jbm.820050207
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发表时间：
1971-03
期刊：
影响因子：
--
通讯作者：
E. J. Frazza;E. Schmitt
中科院分区：
文献类型：
--
作者：
E. J. Frazza;E. Schmitt
尽管由各种合成和天然材料制成的令人满意的不可吸收缝合线已经存在多年，但自古以来只有胶原性可吸收缝合线才被普遍接受。虽然羊肠线和最近开发的再生胶原蛋白是足够的，但它们有许多复杂的天然物质共同的固有缺点，特别是成分和性质的变化。以聚乙醇酸为原料合成了一种新型可吸收缝合线。这种材料是在测试了各种聚合物在动物身上的适当吸收行为以及所需的物理和机械性能后选择的。以乙交酯为原料，通过开环熔融聚合最方便地制备出适合于该用途的聚乙醇酸。对这种商业上无法获得的单体开发可靠的工艺导致发现存在两种乙交酯多晶型，其中一种在接触微量水分后表现出不稳定的聚合行为。聚乙醇酸通过熔融挤出、拉伸和热定形转变为纤维。由这些纤维制成的编织缝合线具有高强度、优良的手感、最小的组织反应性以及与羊肠线相似但更可重复性的吸收率。这些缝合线的临床研究正在进行中。
Although satisfactory nonabsorbable sutures made from a variety of synthetic and natural materials have been available for a number of years, since ancient times only collagenous absorbable sutures have found general acceptance. While adequate, catgut and the more recently developed regenerated collagens have inherent disadvantages common to many complex natural substances, particularly variability in composition and properties. A new synthetic absorbable suture has been developed from polyglycolic acid . This material was chosen after testing a wide variety of polymers for the appropriate absorbability behavior in animals and for the required physical and mechanical properties. Polyglycolic acid suitable for this use was most conveniently prepared by the ring opening melt polymerization of glycolide. Development of a reliable process for this commercially unavailable monomer led to the discovery of the existence of two glycolide polymorphs one of which exhibits erratic polymerization behavior after exposure to trace amounts of moisture. Polyglycolic acid was converted into fiber by melt extrusion, stretching, and heat setting. Braided sutures prepared from these fibers exhibit high strength, excellent handling properties, minimal tissue reactivity, and a similar but more reproducible absorption rate than catgut. Clinical studies with these sutures are in progress.