Comparison between scaling-root-planing (SRP) and SRP/photodynamic therapy: six-month study.
Comparison between scaling-root-planing (SRP) and SRP/photodynamic therapy: six-month study.
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DOI：
10.1186/1746-160x-8-12
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发表时间：
2012-04-05
影响因子：
3
通讯作者：
Willershausen B
中科院分区：
文献类型：
--
作者：
Berakdar M;Callaway A;Eddin MF;Ross A;Willershausen B
这项长期的临床研究的目的是检查光动力疗法（PDT）的附加疗效洁治和根面平整（SRP）的慢性牙周病患者。共有22名患者（平均年龄：59.3 ± 11.7岁）患有慢性牙周病，其中4颗牙齿的探诊深度≥ 5 mm。入选标准为：无全身性疾病、无吸烟史、无妊娠史、无长期服药史。除既往病史外，还在基线（治疗前1周）和治疗后1个月、3个月和6个月评估以下临床参数：探诊出血（BOP）、斑块指数（PI）、探诊深度（PD）和临床附着丧失。所有测量均由同一检查者使用固定牙周探针（PCP 12，Hu-Friedy）以每颗牙齿6次测量完成。在每名患者中，两颗牙齿单独用SRP治疗，两颗牙齿用SRP和PDT治疗（Periowave，Ondine Bioburma，温哥华，加拿大）。使用配对样本的非参数Wilcoxon检验比较两种治疗的效果（p ≤ 0.05）。在这两种类型的治疗后，BOP阳性的牙齿数量下降。基线时，CAL测量值为7.2 ± 1.2 mm（SRP）或8.1 ± 1.3 mm（SRP/PDT）;两种类型治疗后1个月、3个月和6个月均观察到改善。基线时，探测深度为5.9 ± 0.8 mm（SRP）或6.4 ± 0.8 mm（SRP/PDT）; 6个月后，发现改善2.4 ± 0.6 mm（SRP）或2.9 ± 0.8 mm（SRP/PDT）。6个月后，通过SRP/PDT组合实现的PD更大程度的减少具有统计学意义（p = 0.007）。这项临床研究表明，SRP结合PDT似乎是有效的，因此适合作为一种辅助治疗慢性牙周病患者的牙周袋的机械条件。
The purpose of this long-term clinical study was to examine the additional efficacy of photodynamic therapy (PDT) to scaling and root planing (SRP) in patients with chronic periodontal disease. A total of 22 patients (mean age: 59.3 ± 11.7 years) with chronic periodontal disease and four teeth with probing depth ≥ 5 mm were enrolled in the study. Inclusion criteria were: no systemic disease, no smoking, no pregnancy and no long-term medication. Beside the anamnesis, the following clinical parameters were assessed at baseline (one week before therapy), and one, three and six months after the therapy: bleeding on probing (BOP), plaque index (PI) probing depth (PD), and clinical attachment loss. All measurements were done by the same examiner with a fixed periodontal probe (PCP 12, Hu-Friedy) at six measurements/tooth. In each patient, two teeth were treated with SRP alone and two teeth with SRP and PDT (Periowave, Ondine Biopharma, Vancouver, Canada). The nonparametric Wilcoxon test for paired samples was used for comparison of the effect of the two treatments (p ≤ 0.05). After both types of treatment, the number of teeth positive for BOP declined. At baseline, the CAL measured 7.2 ± 1.2 mm (SRP) or 8.1 ± 1.3 mm (SRP/PDT); one, three and six months after both types of treatment an improvement was observed. At baseline, the probing depth was 5.9 ± 0.8 mm (SRP) or 6.4 ± 0.8 mm (SRP/PDT); after six months, an improvement of 2.4 ± 0.6 mm (SRP) or 2.9 ± 0.8 mm (SRP/PDT) was found. The greater reduction of the PD, achieved by a combination of SRP/PDT, was statistically significant after six months (p = 0.007). This clinical study demonstrates that SRP in combination with PDT seems to be effective and is therefore suitable as an adjuvant therapy to the mechanical conditioning of the periodontal pockets in patients with chronic periodontal diseases.