EFFECTS OF ACUTE WATER LOAD, HYPERTONIC SALINE INFUSION, AND FUROSEMIDE ADMINISTRATION ON ATRIAL-NATRIURETIC-PEPTIDE AND VASOPRESSIN RELEASE IN HUMANS
EFFECTS OF ACUTE WATER LOAD, HYPERTONIC SALINE INFUSION, AND FUROSEMIDE ADMINISTRATION ON ATRIAL-NATRIURETIC-PEPTIDE AND VASOPRESSIN RELEASE IN HUMANS
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DOI：
10.1210/jcem-62-5-1003
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发表时间：
1986-05-01
影响因子：
5.8
通讯作者：
YOSHINAGA, K
中科院分区：
文献类型：
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作者：
KIMURA, T;ABE, K;YOSHINAGA, K
用于α-人心房钠尿激素(αhANP)的新的特异性RIA用于确定由急性水负荷、高渗盐水输注和速尿施用引起的血浆容量的变化是否引起正常受试者中ANP释放的变化以及由此导致的肾功能和心血管功能的变化。此外，还同时研究了血浆精氨酸加压素（AVP）、PRA和醛固酮浓度的变化。平均血浆αhANP和AVP水平为51.3±。 16.0 (.+-.SE) 和 3.1 .+-.基础状态下分别为 0.6 pg/ml。血浆.alpha.hANP升至77.8.+-。 27.6响应水负荷引起的血浆体积4.5%的增加，进一步增加至134.1.+-。 28.9 响应高渗盐水引起的 23% 体积增加，并下降至 70.2.+-。 15.8 pg/ml，响应呋塞米治疗后血浆容量的减少（P < 0.01-0.05）。另一方面，血浆AVP下降至1.8.+-。水负载后0.1 pg/ml，升至4.1.+-。高渗盐水后为0.6，并进一步升至5.8.+-。呋塞米后为 0.8 pg/ml (P < 0.01-0.05)。水和高渗盐水负荷降低了 PRA，但血浆醛固酮浓度没有变化；随后给予速尿后两者均增加（P < 0.01-0.05）。动脉压和心率没有显着变化。尿Na排泄和渗透清除率的增加与水负荷和高渗盐水输注后血浆αhANP的升高相关(P<0.01-0.05)，但尿流量的变化主要与AVP释放的改变相关。
The new specific RIA for .alpha.-human atrial natriuretic hormone (.alpha.hANP) was used to determine whether changes in plasma volume elicited by acute water loading, hypertonic saline infusion, and furosemide administration caused changes in ANP release and resultant changes in renal and cardiovascular function in normal subjects. In addition, changes in plasma arginine vasopressin (AVP), PRA, and aldosterone concentrations were studied simultaneously. Mean plasma .alpha.hANP and AVP levels were 51.3 .+-. 16.0 (.+-. SE) and 3.1 .+-. 0.6 pg/ml, respectively, in the basal state. Plasma .alpha.hANP rose to 77.8 .+-. 27.6 in response to a 4.5% increase in plasma volume induced by water loading, increased further to 134.1 .+-. 28.9 in reponse to a 23% volume increase induced by hypertonic saline, and fell to 70.2 .+-. 15.8 pg/ml in response to a decrease in plasma volume after furosemide treatment (P < 0.01-0.05). On the other hand, plasma AVP fell to 1.8 .+-. 0.1 pg/ml after the water load, rose to 4.1 .+-. 0.6 after hypertonic saline, and rose further to 5.8 .+-. 0.8 pg/ml after furosemide (P < 0.01-0.05). Water and hypertonic saline loading decreased PRA, but plasma aldosterone concentrations did not change; subsequent furosemide administration increased both (P < 0.01-0.05). Arterial pressure and heart rate did not change significnatly. Increases in urinary Na excretion and osmolar clearances were associated with a rise in plasma .alpha.hANP after water loading and hypertonic saline infusion (P < 0.01-0.05), but changes in urine flow were mainly associated with alterations in AVP release.