Phenylbutazone toxicosis in equidae: a biochemical and pathophysiological study.
Phenylbutazone toxicosis in equidae: a biochemical and pathophysiological study.
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马科保泰松中毒：一项生化和病理生理学研究。
DOI：
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发表时间：
1981
影响因子：
1
通讯作者：
P. Holmes
中科院分区：
文献类型：
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作者：
D. Snow;T. Douglas;H. Thompson;J. Parkins;P. Holmes
采用多种生化、病理生理和病理学方法，研究了保泰松（PBZ）对马和矮种马的毒性作用。在10 - 12 mg/kg体重/天的剂量水平下持续8 - 10天，小马经常出现以低蛋白血症为特征的中毒临床体征。使用51 CrCl 3的研究表明，PBZ引起蛋白质丢失性胃肠病。血浆损失通常与胃肠道溃疡相关，但有时在轻度受累动物中发生，无明显病变。在纯种犬中进行的类似研究（8.2 mg/kg/天，持续13天）表明，它们对PBZ毒性的敏感性较低;然而，在6只给药纯种犬中有4只发生了一定程度的低蛋白血症。
Toxic effects of phenylbutazone (PBZ) in ponies and horses were studied, using a variety of biochemical, pathophysiologic, and pathologic methods. At dosage levels of 10 to 12 mg/kg of body weight/day for 8 to 10 days, ponies frequently developed clinical signs of toxicosis characterized by hypoproteinemia. Studies using 51CrCl3 demonstrated that PBZ caused a protein-losing gastroenteropathy. The plasma loss was usually associated with gastrointestinal ulceration, but sometimes occurred without obvious lesions in mildly affected animals. Similar studies (8.2 mg/kg/day for 13 days) in Thoroughbreds indicated that they were less susceptible to PBZ toxicity; however, a degree of hypoproteinemia occurred in 4 of 6 treated Thoroughbreds.