Glucagon-like peptide 1 and glucose-dependent insulinotropic polypeptide: new advances
Glucagon-like peptide 1 and glucose-dependent insulinotropic polypeptide: new advances
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DOI：
10.1097/med.0b013e3283339051
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发表时间：
2010-02-01
影响因子：
3.2
通讯作者：
Holst, Jens J.
中科院分区：
文献类型：
--
作者：
Asmar, Meena;Holst, Jens J.
综述目的本文重点介绍了我们对胰高血糖素样肽 1 (GLP-1) 和葡萄糖依赖性促胰岛素多肽 (GIP) 生理学及其在肠促胰岛素作用之外的各种作用位点的理解的最新进展。最新发现 GLP-1 和 GIP 均以葡萄糖依赖性方式刺激胰岛素分泌，因此被归类为肠促胰岛素。除了葡萄糖依赖性胰岛素分泌之外，这些肽对胰岛β细胞也有共同作用，导致β细胞增殖和抵抗细胞凋亡。然而，GLP-1和GIP的作用并不限于胰岛细胞；它们在许多器官中具有调节功能。最近的证据表明 GLP-1 对心血管系统和中枢神经系统具有重要的有益作用。 GIP 可能在促进人体能量储存、通过刺激成骨细胞增殖和抑制细胞凋亡来增强骨形成方面发挥作用，并且可能在中枢神经系统功能中发挥作用。总结这些新发现表明这些激素可进一步应用于治疗心血管疾病和肥胖等疾病。
Purpose of reviewThis article highlights recent advances in our understanding of glucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) physiology and their various sites of action beyond the incretin effect.Recent findingsBoth GLP-1 and GIP stimulate insulin secretion in a glucose-dependent manner and are thus classified as incretins. Beyond glucose-dependent insulin secretion, the peptides have common actions on islet beta cells, leading beta-cell proliferation and resistance to apoptosis. However, the action of GLP-1 and GIP is not limited to the islet cells; they have regulatory functions in many organs. Recent evidence has suggested that GLP-1 has important beneficial effects in the cardiovascular system and central nervous system. GIP may play a role in promoting energy storage in humans, enhances bone formation via stimulation of osteoblast proliferation and inhibition of apoptosis and may play a role in central nervous system function.SummaryThese new findings suggest further application of these hormones for the treatment of conditions such as cardiovascular disease and obesity.