Long-term potentiation in spinal nociceptive systems -: how acute pain may become chronic
Long-term potentiation in spinal nociceptive systems -: how acute pain may become chronic
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DOI：
10.1016/j.psyneuen.2005.04.007
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发表时间：
2005-11-01
影响因子：
3.7
通讯作者：
Tjolsen, A
中科院分区：
文献类型：
--
作者：
Rygh, LJ;Svendsen, F;Tjolsen, A
慢性疼痛是一个主要问题，因为它很难治疗，对潜在的神经生物学的理解很少。急性疼痛转变为慢性疼痛的机制尚不清楚。然而，脊髓伤害性系统中的长时程增强（LTP）可能是一种这样的机制。在此，我们简要回顾了有关脊髓伤害性系统LTP的文献，包括我们自己的关于深会聚伤害性神经元LTP的数据。此外，我们讨论了这种现象在理解慢性疼痛的神经生物学和可能的治疗意义的作用。(c)2005爱思唯尔有限公司保留所有权利。
Chronic pain is a major problem since it is difficult to treat and the understanding of the underlying neurobiology is sparse. The mechanisms underpinning the transition of acute into chronic pain remain unclear. However, long-term potentiation (LTP) in spinal nociceptive systems may be one such mechanism. Here, we briefly review the Literature regarding LTP in spinal nociceptive systems including our own data on LTP in deep convergent nociceptive neurons. Furthermore, we discuss the role of this phenomenon in understanding the neurobiology of chronic pain and the possible therapeutic implications. (c) 2005 Elsevier Ltd. All rights reserved.