Factor VIIa interaction with tissue factor and endothelial cell protein C receptor on cell surfaces.
Factor VIIa interaction with tissue factor and endothelial cell protein C receptor on cell surfaces.
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DOI：
10.1053/j.seminhematol.2008.03.014
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发表时间：
2008-04
影响因子：
3.6
通讯作者：
U. Pendurthi;L. M. Rao
中科院分区：
文献类型：
--
作者：
U. Pendurthi;L. M. Rao
因子VIIa（FVIIa）是触发凝血级联激活的酶，最终导致纤维蛋白沉积和血小板激活。FVIIa与其细胞受体组织因子（TF）的结合大大增加了FVIIa的酶活性，对于有效启动凝血途径至关重要。FVIIa还与内皮细胞蛋白C受体（EPCR）复合，但这种结合不增加FVIIa的酶活性。本文综述了目前的知识FVIIa与TF和EPCR的细胞表面上的相互作用，特别关注这些相互作用如何可能有助于FVIIa和TF清除，从而调节TF-FVIIa活性。
Factor VIIa (FVIIa) is the enzyme that triggers activation of the clotting cascade that eventually leads to fibrin deposition and platelet activation. Association of FVIIa with its cellular receptor, tissue factor (TF), which greatly increases FVIIa enzymatic activity, is essential for the effective initiation of the coagulation pathway. FVIIa also complexes with endothelial cell protein C receptor (EPCR), but this association does not increase the enzymatic activity of FVIIa. This article reviews current knowledge of FVIIa interaction with TF and EPCR on cell surfaces with a specific focus on how these interactions may contribute to FVIIa and TF clearance, thereby regulating TF-FVIIa activity.