Prevalence of colon polyps detected by colonoscopy screening in asymptomatic black and white patients
Prevalence of colon polyps detected by colonoscopy screening in asymptomatic black and white patients
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DOI：
10.1001/jama.300.12.1417
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发表时间：
2008-09-24
影响因子：
120.7
通讯作者：
Morris, Cynthia D.
中科院分区：
文献类型：
--
作者：
Lieberman, David A.;Holub, Jennifer L.;Morris, Cynthia D.
背景与白人相比，黑人男性和女性结直肠癌的发病率和死亡率更高，并且患癌症的年龄可能更年轻。如果癌症前驱病变的年龄调整患病率和位置存在种族差异，结直肠癌筛查对黑人的效果可能较差。 目的 确定并比较接受结肠镜检查的无症状黑人和白人中直径超过 9 毫米的息肉的患病率和位置。 设计、设置和患者 结肠镜检查数据前瞻性地从 67 名成人胃肠病诊所收集 2004 年 1 月 1 日至 2005 年 12 月 31 日期间，使用计算机内窥镜报告生成器在美国多个站点进行数据传输。数据被传输到中央数据库，其中识别出所有接受结肠镜筛查的无症状白人 (n = 80 061) 和黑人 (n = 5464) 患者。 主要结果指标 大小超过 9 毫米的息肉的患病率和位置，并根据年龄、性别和家庭进行调整的历史 结果 与白人男性和女性相比，黑人男性和女性直径超过 9 毫米的息肉患病率较高（422 [ 7.7%] vs 4964 [ 6.2%]；P
Context Compared with white individuals, black men and women have a higher incidence and mortality from colorectal cancer and may develop cancer at a younger age. Colorectal cancer screening might be less effective in black individuals, if there are racial differences in the age- adjusted prevalence and location of cancer precursor lesions.Objectives To determine and compare the prevalence rates and location of polyps sized more than 9 mm in diameter in asymptomatic black and white individuals who received colonoscopy screening.Design, Setting, and Patients Colonoscopy data were prospectively collected from 67 adult gastrointestinal practice sites in the United States using a computerized endoscopic report generator between January 1, 2004, and December 31, 2005. Data were transmitted to a central data repository, where all asymptomatic white ( n = 80 061) and black ( n= 5464) patients who had received screening colonoscopy were identified.Main Outcome Measures Prevalence and location of polyps sized more than 9 mm, adjusted for age, sex, and family history of colorectal cancer in a multivariate analysis.Results Both black men and women had a higher prevalence of polyps sized more than 9 mm in diameter compared with white men and women ( 422 [ 7.7%] vs 4964 [ 6.2%]; P