Synthesis of 1,1-Diboron Alkanes via Diborylation of Unactivated Primary C(sp3)-H Bonds Enabled by AsPh3/Iridium Catalysis
Synthesis of 1,1-Diboron Alkanes via Diborylation of Unactivated Primary C(sp3)-H Bonds Enabled by AsPh3/Iridium Catalysis
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DOI：
10.6023/cjoc202111032
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发表时间：
2022-04-01
影响因子：
1.9
通讯作者：
Xu Senmiao
中科院分区：
文献类型：
--
作者：
Liu Wenqi;Shen Zhenlu;Xu Senmiao
公开了使用吡唑作为导向基团的AsPh3/铱催化的未活化的伯C(sp(3))-H键的二硼基化。该方法可以耐受多种官能团，以中等至良好的收率提供大量 1,1-二硼碱。还证明了当前方法在克级反应中用于进一步功能化的合成效用。
The AsPh3/iridium catalyzed diborylation of unactivated primary C(sp(3))-H bonds using pyrazoles as directing groups was disclosed. This method could tolerate a variety of functional groups, affording a vast array of 1,1-diboron alkalies in moderate to good yields. The synthetic utility of the current method on a gram-scale reaction for further functionalization was also demonstrated.