SERUM INTERLEUKIN-6 CONCENTRATION IN SCHIZOPHRENIA - ELEVATION ASSOCIATED WITH DURATION OF ILLNESS
SERUM INTERLEUKIN-6 CONCENTRATION IN SCHIZOPHRENIA - ELEVATION ASSOCIATED WITH DURATION OF ILLNESS
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DOI：
10.1016/0165-1781(94)90042-6
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发表时间：
1994-01-01
影响因子：
11.3
通讯作者：
RABIN, BS
中科院分区：
文献类型：
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作者：
GANGULI, R;YANG, ZW;RABIN, BS
采用酶免疫分析法检测了128例精神分裂症患者(其中24例未服药)和110例正常人的血清白介素6(IL-6)水平。精神分裂症患者血清IL-6平均浓度显著高于对照组(P=0.009)。患者组内比较，血清IL-6水平与病程显著相关(r=0.32，p=0.0004)。在病程协变后，IL-6水平与自身抗体的产生、临床状态或药物状态之间没有关系。因此，精神分裂症患者在病程中血清IL-6水平升高，可能与治疗或疾病进展有关。
Using an enzyme immunoassay (ELISA), we measured serum interleukin-6 (IL-6) concentration in 128 schizophrenic patients (24 of whom were never medicated) and in 110 normal control subjects. Mean serum IL-6 concentration was significantly higher in the schizophrenic patients as compared with the control subjects (p = 0.009). Comparisons within the patient group revealed that serum IL-6 was significantly correlated with duration of illness (r = 0.32, p = 0.0004). After covariation for duration of illness, there was no relationship between IL-6 levels and the production of autoantibodies, clinical state, or medication status. Thus, elevated serum IL-6 levels in schizophrenia develop during the course of illness and may be related to treatment or to disease progression.