Lipoprotein (a) and coronary artery calcification: prospective study assessing interactions with other risk factors.
Lipoprotein (a) and coronary artery calcification: prospective study assessing interactions with other risk factors.
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DOI：
10.1016/j.metabol.2021.154706
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发表时间：
2021-03
期刊：
影响因子：
--
通讯作者：
Tabet F
中科院分区：
文献类型：
--
作者：
Ong KL;McClelland RL;Allison MA;Cushman M;Garg PK;Tsai MY;Rye KA;Tabet F
血浆脂蛋白（a）[Lp（a）]升高和冠状动脉钙化（CAC）是相互关联的心血管危险因素。我们假设其他心血管危险因素可能会影响他们的关系。我们在5975名多种族动脉粥样硬化研究（梅萨）参与者中测试了与血脂异常、糖尿病、胰岛素抵抗、高血压、炎症和凝血相关的24个研究变量与基线Lp（a）在9.5年内CAC体积和密度变化的相互作用，基线时无明显心血管疾病。Lp（a）升高与CAC体积的绝对增加较大相关（Lp（a）≥30与<30 mg/dL，Lp（a）≥50与<50 mg/dL分别高3.21和4.45 mm 3/年），但CAC体积的相对变化无关。当评估连续ln转化的Lp（a）时，未发现与CAC密度变化相关。Lp（a）升高与在白细胞介素2可溶性受体α、可溶性肿瘤坏死因子α受体1和纤维蛋白原循环水平较高的参与者中，（四分位数4分别为15.33、11.81和7.02 mm 3/年，而四分位数1分别为-3.44、-0.59和1.91 mm 3/年）。其他研究变量没有发现显著的相互作用。当评估Lp（a）水平≥50 mg/dL时，观察到类似的相互作用。Lp（a）升高与CAC体积的绝对增加相关，特别是在炎症和凝血的选定标志物水平较高的参与者中。这些结果表明Lp（a）是CAC体积进展的潜在生物标志物。
Elevated plasma lipoprotein (a) [Lp(a)] and coronary artery calcification (CAC) are established cardiovascular risk factors that correlate with each other. We hypothesized that other cardiovascular risk factors could affect their relationship. We tested for interactions of 24 study variables related to dyslipidemia, diabetes, insulin resistance, hypertension, inflammation and coagulation with baseline Lp(a) on change in CAC volume and density over 9.5 years in 5975 Multi-Ethnic Study of Atherosclerosis (MESA) participants, free of apparent cardiovascular disease at baseline. Elevated Lp(a) was associated with larger absolute increase in CAC volume (3.21 and 4.45 mm3/year higher for Lp(a) ≥30 versus <30 mg/dL, and Lp(a) ≥50 versus <50 mg/dL, respectively), but not relative change in CAC volume. No association was found with change in CAC density when assessing continuous ln-transformed Lp(a). The association between elevated Lp(a) (≥30 mg/dL) and absolute change in CAC volume was greater in participants with higher circulating levels of interleukin-2 soluble receptor α, soluble tumor necrosis factor alpha receptor 1 and fibrinogen (15.33, 11.81 and 7.02 mm3/year in quartile 4, compared to −3.44, −0.59 and 1.91 mm3/year in quartile 1, respectively). No significant interaction was found for other study variables. Similar interactions were seen when assessing Lp(a) levels ≥50 mg/dL. Elevated Lp(a) was associated with an absolute increase in CAC volume, especially in participants with higher levels of selected markers of inflammation and coagulation. These results suggest Lp(a) as a potential biomarker for CAC volume progression.
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影响因子：
120.7
作者：
Erqou, Sebhat;Kaptoge, Stephen;Perry, Philip L.;Di Angelantonio, Emanuele;Thompson, Alexander;White, Ian R.;Marcovina, Santica M.;Collins, Rory;Thompson, Simon G.;Danesh, John
通讯作者：
Danesh, John
影响因子：
20.1
作者：
Ambale-Venkatesh B;Yang X;Wu CO;Liu K;Hundley WG;McClelland R;Gomes AS;Folsom AR;Shea S;Guallar E;Bluemke DA;Lima JAC
通讯作者：
Lima JAC
影响因子：
6.2
作者：
Anderson, Todd J.;Gregoire, Jean;Ward, Richard
通讯作者：
Ward, Richard
DOI：
10.1161/atvbaha.107.153668
发表时间：
2007-12-01
影响因子：
8.7
作者：
Al-Aly, Ziyad;Shao, Jian-Su;Towler, Dwight A.
通讯作者：
Towler, Dwight A.
影响因子：
24
作者：
Grundy, Scott M.;Stone, Neil J.;Wijeysundera, Duminda N.
通讯作者：
Wijeysundera, Duminda N.