An update on complex I assembly: the assembly of players.
An update on complex I assembly: the assembly of players.
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DOI：
10.1007/s10863-014-9564-x
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发表时间：
2014-08
影响因子：
3
通讯作者：
Bai, Yidong
中科院分区：
文献类型：
--
作者：
Vartak, Rasika S.;Semwal, Manpreet Kaur;Bai, Yidong
Defects in Complex I assembly is one of the emerging underlying causes of severe mitochondrial disorders. The assembly of Complex I has been difficult to understand due to its large size, dual genetic control and the number of proteins involved. Mutations in Complex I subunits as well as assembly factors have been reported to hinder its assembly and give rise to a range of mitochondria disorders. In this review, we summarize the recent progress made in understanding the Complex I assembly pathway. In particularly, we focus on the known as well as novel assembly factors and their role in assembly of Complex I and human disease.
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