Structural Study of Nicotine Salts
Structural Study of Nicotine Salts
复制标题
尼古丁盐的结构研究
DOI：
--
复制
发表时间：
1983
期刊：
影响因子：
--
通讯作者：
T.A. Perfetti
中科院分区：
文献类型：
--
作者：
T.A. Perfetti
测定了三种烟碱盐的结构。这些盐具有1：1、2：1或3：1的酸碱比。有机酸和尼古丁之间的成盐取决于酸的结构（脂肪族或芳香族）及其功能。尼古丁的1：1盐具有与尼古丁的N-甲基吡咯烷氮结合的氨基酸或苯甲酸型酸。发现2：1盐与1：1盐中的一个酸基结合，第二个酸基与吡啶环的氮结合。尼古丁的2：1盐与甲酸、脂族二羧酸和/或硝基芳族酸形成。尼古丁与脂肪族一元羧酸形成3：1的盐，起始于乙酸。这里，一种酸如在1：1盐中那样结合，而另外两种酸二聚化并结合到吡啶基团的氮上。采用红外光谱、紫外光谱、质子核磁共振、碳核磁共振以及场解吸-质谱等方法对烟碱盐的结构进行了研究。
Abstract The structures of three types of nicotine salts have been determined. These salts have acid to base ratios of either 1 : 1, 2 : 1, or 3 : 1. Salt formation between organic acids and nicotine is dependent upon the structure of the acids (aliphatic or aromatic) and their functionality. The 1 : 1 salts of nicotine have amino acids or benzoic-type acids bound to the N-methylpyrrolidine nitrogen of nicotine. The 2 : 1 salts are found to bind to one acid group as in the 1 : 1 salts and a second to the nitrogen of the pyridine ring. The 2 : 1 salts of nicotine are formed with formic acid, aliphatic dicarboxylic acids, and/or nitroaromatic acids. Nicotine forms 3 : 1 salts with aliphatic monocarboxylic acids starting with acetic acid. Here one acid is bound as in the 1 : 1 salts while the other two acids dimerize and bind to the nitrogen of the pyridine group. Infra-red (IR), ultra-violet (UV), proton nuclear magnetic resonance (PMR), and carbon nuclear magnetic resonance (CMR) spectroscopy as well as field desorption - mass spectroscopy (FD-MS) were used in this investigation of the structure of nicotine salts.