PROCESSING CONSIDERATIONS FOR AN EC LATEX COATING SYSTEM - INFLUENCE OF CURING TIME AND TEMPERATURE
PROCESSING CONSIDERATIONS FOR AN EC LATEX COATING SYSTEM - INFLUENCE OF CURING TIME AND TEMPERATURE
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DOI：
10.1023/a:1018960310144
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发表时间：
1994-10-01
影响因子：
3.7
通讯作者：
SAKR, A
中科院分区：
文献类型：
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作者：
HUTCHINGS, D;KUZMAK, B;SAKR, A
使用响应面法评估固化时间和固化温度对市售乙基纤维素乳胶涂料分散体（Aquacoat（R））的影响。因素固化时间的水平范围为30至300分钟，而固化温度的水平范围为45至75摄氏度。响应值A、kappa和γ来自溶出曲线的回归分析，分别对应于12小时采样期内释放的最大药物量、释放速率和溶出曲线的拐点。响应面的性质受到掺入涂料配方中的增塑剂的显著影响。当使用癸二酸酯作为增塑剂时，当样品暴露于更高的固化温度或储存更长的时间段时，产生更快的释放（更高的A和κ值，更低的γ值）。特别地，当使用柠檬酸三丁酯作为增塑剂时，当样品暴露于更严格的条件时，释放较慢。总的来说，固化温度比固化时间具有更显著的影响。
The influence of curing time and curing temperature for a commercially available ethylcellulose latex coating dispersion (Aquacoat((R))) were evaluated using response surface methodology. Levels for the factor curing time ranged from 30 to 300 minutes while levels for curing temperature ranged from 45 degrees to 75 degrees C. Responses, A, kappa, and gamma, were derived from regression analysis of the dissolution profiles and correspond to the maximum amount of drug released over the 12 hour sampling period, the rate of release, and the inflection point of the dissolution profile, respectively. The nature of the response surface was dramatically influenced by the plasticizer incorporated into the coating formula. When dibutyl sebacate was employed as the plasticizer, faster release resulted (higher A and kappa values, lower gamma values) when samples were exposed to higher curing temperatures or were stored for longer periods of time. Paradoxically, when tributyl citrate was used as the plasticizer, slower release resulted when samples were exposed to more rigorous conditions. Overall, curing temperature had a more dramatic effect than curing time.