Brain Activity During Cocaine Craving and Gambling Urges: An fMRI Study
Brain Activity During Cocaine Craving and Gambling Urges: An fMRI Study
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DOI：
10.1038/npp.2015.193
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发表时间：
2016-01-01
影响因子：
7.6
通讯作者：
Potenza, Marc N.
中科院分区：
文献类型：
--
作者：
Kober, Hedy;Lacadie, Cheryl M.;Potenza, Marc N.
虽然渴求状态对可卡因依赖（CD）和病理性赌博（PG）都很重要，但很少有研究直接研究这些疾病之间渴求的神经生物学相似性和差异。我们使用功能性磁共振成像（fMRI）来评估103名参与者（30名CD，28名PG和45名对照）的大脑活动，同时他们观看了描述可卡因，赌博和悲伤场景的视频，以研究渴望的神经相关性。在自我报告的渴望中，我们观察到一种三向冲动类型X视频类型X诊断组互动，CD参与者对可卡因视频报告强烈的可卡因渴望，PG参与者对赌博视频报告强烈的赌博冲动。神经影像学数据显示，前扣带皮层/腹内侧前额叶皮层（mPFC）的诊断组X视频互动，主要激活CD参与者的可卡因视频，以及一个更背侧的mPFC区域，CD参与者的可卡因视频，PG参与者的赌博视频和控制参与者的悲伤视频最强烈地激活。性别x诊断x视频互动确定背侧mPFC和一个区域在后丘脑/尾状核，其中女性而不是男性PG参与者表现出增加的反应赌博视频。研究结果说明了在CD和PG的药物渴望和赌博冲动的神经相关性的相似性和差异。未来的研究应该调查诊断和性别特异性治疗，针对神经系统的渴望/冲动成瘾状态。
Although craving states are important to both cocaine dependence (CD) and pathological gambling (PG), few studies have directly investigated neurobiological similarities and differences in craving between these disorders. We used functional magnetic resonance imaging (fMRI) to assess brain activity in 103 participants (30 CD, 28 PG, and 45 controls) while they watched videos depicting cocaine, gambling, and sad scenarios to investigate the neural correlates of craving. We observed a three-way urge type x video type x diagnostic group interaction in self-reported craving, with CD participants reporting strong cocaine cravings to cocaine videos, and PG participants reporting strong gambling urges to gambling videos. Neuroimaging data revealed a diagnostic group x video interaction in anterior cingulate cortex/ventromedial prefrontal cortex (mPFC), activating predominantly to cocaine videos in CD participants, and a more dorsal mPFC region that was most strongly activated for cocaine videos in CD participants, gambling videos in PG participants, and sad videos in control participants. Gender x diagnosis x video interactions identified dorsal mPFC and a region in posterior insula/caudate in which female but not male PG participants showed increased responses to gambling videos. Findings illustrate both similarities and differences in the neural correlates of drug cravings and gambling urges in CD and PG. Future studies should investigate diagnostic-and gender-specific therapies targeting the neural systems implicated in craving/urge states in addictions.