Previous stress increases in vivo biogenic amine response to swim stress.
Previous stress increases in vivo biogenic amine response to swim stress.
复制标题
先前的压力会增加体内生物胺对游泳压力的反应。
DOI：
10.1007/bf00969000
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发表时间：
1994
影响因子：
4.4
通讯作者：
Petty,F
中科院分区：
文献类型：
--
作者：
Jordan,S;Kramer,GL;Zukas,PK;Petty,F
采用体内微透析法测定连续2天8分钟游泳应激大鼠内侧前额叶皮层生物胺含量。在应激第一天，应激后去甲肾上腺素（NE）外排比基线增加183%，而多巴胺（DA）和血清素（5-HT）始终保持稳定。在应激第二天，所有3种神经递质均显著增加，（NE）、（DA）和（5-HT）分别增加310%、441%和496%，并在应激后1小时或更长时间内保持升高。这表明，首次暴露于游泳压力，虽然没有引起生物胺释放的剧烈变化，但可能使内侧前额叶皮层的生物胺对随后的游泳压力敏感。我们的研究结果也为神经化学变化提供了初步数据，这些变化可能是“行为绝望”强迫游泳模型的基础。
In vivo microdialysis was used to determine biogenic amines in medial prefrontal cortex of rats exposed to eight minutes of swim stress on two consecutive days. On the first day of stress, norepinephrine (NE) efflux increased by 183% over baseline after stress, while dopamine (DA) and serotonin (5-HT) remained stable throughout. On the second day of stress, a robust increase was observed in all 3 neurotransmitters measured, with (NE), (DA), and (5-HT) increasing by 310%, 441% and 496% respectively, and remaining elevated for an hour or more after stress. This suggests that the first exposure to swim stress, while not causing dramatic changes in biogenic amine release, may sensitize biogenic amines in medial prefrontal cortex to subsequent swim stress. Our results also serve as preliminary data concerning the neurochemical changes which might underlie the forced swimming model of “behavioral despair”.