Measured Body Mass Index in Adolescence and the Incidence of Colorectal Cancer in a Cohort of 1.1 Million Males
Measured Body Mass Index in Adolescence and the Incidence of Colorectal Cancer in a Cohort of 1.1 Million Males
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DOI：
10.1158/1055-9965.epi-11-0531
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发表时间：
2011-12-01
影响因子：
3.8
通讯作者：
Shamiss, Ari
中科院分区：
文献类型：
--
作者：
Levi, Zohar;Kark, Jeremy D.;Shamiss, Ari
背景和目的：青少年肥胖症的日益流行影响着成年人的健康。我们调查了青少年超重与结直肠癌的发病率在一个大的队列males.Methods：身体质量指数（BMI）的关联进行了测量，在110万犹太以色列男性谁在1967年至2005年之间的16至19岁的一般健康检查。超重定义为BMI >=标准U的第85百分位数。S.青春期的分布结直肠癌是通过与以色列国家癌症登记处的联系确定的，直到2006年。平均随访期为17.6 +/- 10.9年，反映了1950万人年。结果：在前10年和后10年的年度检查队列中，青少年超重的患病率从9.9%增加到16.8%。结肠癌445例，直肠癌193例。超重可预测结肠癌风险增加[HR 1.53; 95%置信区间（CI），1.17-2.02，P = 0.002]，但不能预测直肠癌风险增加（HR = 1.09; 95% CI，0.38-1.73，P = 0.72）。结肠非粘液腺癌的风险最大（HR 1.68，95% CI，1.26-2.23，P = 0.001）。BMI >= 85 th百分位数与结肠癌的关联在仅限于男性的分析中更为明显，随访至至少40岁[N = 367，478; HR = 1.75（95%CI，1.33-2.3，P < 0.001）]。青少年超重与青年至中年人的结肠癌发病率密切相关。影响：这些长期后遗症增加了认真解决儿童和青少年肥胖问题的紧迫性，其伴随的人口影响越来越大。癌症流行病学生物标志物Prev; 20（12）; 2524-31。(C)2011年AACR。
Background and Aims: The increasing prevalence of adolescent obesity affects adult health. We investigated the association of adolescent overweight with colorectal cancer incidence in a large cohort of males.Methods: Body mass index (BMI) was measured in 1.1 million Jewish Israeli males who underwent a general health examination at ages 16 to 19 between 1967 and 2005. Overweight was defined as BMI >= 85th percentile of the standard U. S. distribution in adolescence. Colorectal cancer was identified by linkage with the Israel National Cancer Registry up to 2006. The mean follow-up period was 17.6 +/- 10.9 years, reflecting 19.5 million person-years. Cox proportional hazards modeling was used.Results: The prevalence of adolescent overweight increased from 9.9% to 16.8% in the first 10 and last 10 annual examination cohorts. Colon (n = 445) and rectal cancer (n = 193) cases were detected. Overweight predicted an increased risk of colon cancer [HR 1.53; 95% confidence interval (CI), 1.17-2.02, P = 0.002] but not of rectal cancer (HR = 1.09; 95% CI, 0.38-1.73, P = 0.72). The risk was greatest for nonmucinous adenocarcinoma of the colon (HR 1.68, 95% CI, 1.26-2.23, P = 0.001). The association of BMI >= 85th percentile with colon cancer was even more pronounced in analyses that were restricted to men followed until at least 40 years of age [N = 367,478; HR = 1.75 (95% CI, 1.33-2.3, P < 0.001)].Conclusions: Adolescent overweight is substantially associated with colon cancer incidence in young to middle-aged adults.Impact: These long-term sequelae add to the urgency to seriously address increasing childhood and adolescent obesity with its attendant increasing population impact. Cancer Epidemiol Biomarkers Prev; 20(12); 2524-31. (C) 2011 AACR.