White matter microstructure between the pre-SMA and the cingulum bundle is related to response conflict in healthy subjects.
White matter microstructure between the pre-SMA and the cingulum bundle is related to response conflict in healthy subjects.
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DOI：
10.1002/brb3.375
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发表时间：
2015-10
影响因子：
3.1
通讯作者：
Ozaki N
中科院分区：
文献类型：
--
作者：
Yamamoto M;Kushima I;Kimura H;Hayashi A;Kawano N;Aleksic B;Iidaka T;Ozaki N
反应冲突包括选择性地关注相关信息和抑制分散注意力的不相关信息。内侧额叶皮质（MFC）被认为参与反应冲突。然而，目前还不清楚哪种白色物质连接与反应冲突有关。本研究的目的是描述反应冲突的神经连接在健康的受试者，并探讨之间的关系白色物质的微观结构和反应冲突任务的表现。28名健康受试者在Flanker任务和弥散MRI期间接受了功能性磁共振成像（fMRI）。我们使用fMRI识别了前辅助运动区（presupplementary motor area，pre-SMA）。此外，我们使用概率纤维束成像描绘了SMA前体和位于MFC中的扣带束（CB）之间的白色连接。我们计算了平均扩散率（MD），白色物质的微观结构的指数，这道和评估MD和性能的侧卫任务之间的关联。这道的平均MD与侧卫任务的表现显著正相关。本研究表明，SMA前体和CB之间的白色连接与健康受试者的反应冲突有关，更精细的白色微结构与更小的反应冲突相关。
Response conflict involves selectively attending to relevant information and suppressing distracting, irrelevant information. The medial frontal cortex (MFC) is considered to be involved in response conflict. However, it remains unclear which white matter connectivity is associated with response conflict. This study aimed to delineate the neural connectivity of response conflict in healthy subjects and investigate the association between white matter microstructure and performance of a response conflict task. Twenty‐eight healthy subjects underwent functional magnetic resonance imaging (fMRI) during the Flanker task and diffusion MRI. We identified the presupplementary motor area (pre‐SMA) using fMRI. Furthermore, we delineated the white matter connectivity between the pre‐SMA and the cingulum bundle (CB), which is located in the MFC, using probabilistic tractography. We calculated the mean diffusivity (MD), index of white matter microstructure, of this tract and evaluate the association between MD and performance of the Flanker task. The mean MD of this tract was significantly and positively associated with performance of the Flanker task. The present study suggests the white matter connectivity between the pre‐SMA and the CB is related to the response conflict in healthy subjects and finer white matter microstructure is associated with smaller response conflict.